Multidrug-Resistant and Extensively Drug Resistant Tuberculosis in Kashmir, India

  • Bikram Singh Datta Government Medical College associated Chest Diseases Hospital, Srinagar, Kashmir
  • Ghulam Hassan Department of Medicine, Government Medical College associated SMHS Hospital, Srinagar, Kashmir
  • Syed Manzoor Kadri Regional Institute of Health and FW, DHS, Srinagar, Kashmir
  • Waseem Qureshi Government Medical College associated SMHS Hospital, Srinagar, Kashmir
  • Mustadiq Ahmad Kamili Department of Medicine, Government Medical College associated SMHS Hospital, Srinagar, Kashmir
  • Hardeep Singh Department of Medicine, Government Medical College associated SMHS Hospital, Srinagar, Kashmir
  • Ahmad Manzoor Department of Medicine, Government Medical College associated SMHS Hospital, Srinagar, Kashmir
  • Mushtaq Ahmad Wani Department of Medicine, Government Medical College associated SMHS Hospital, Srinagar, Kashmir
  • Shamas u Din Department of Chest Medicine, Government Medical College and associated Chest Diseases Hospital, Srinagar, Kashmir
  • Natasha Thakur Department of Surgery , Sheri Kashmir Institute of Medical Sciences , Kashmir
Keywords: tuberculosis, multidrug-resistant tuberculosis, extensively drug resistant tuberculosis, drug susceptibility testing

Abstract

Background: To study the profile of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) in tertiary care hospital setting, representing almost the whole affected population in Kashmir valley of India.

Methodology: A total of 910 cases of pulmonary tuberculosis were enrolled over four years. Among these, cases of MDR-TB and XDR-TB were meticulously studied for drug susceptibility, treatment, adverse effects profile and overall survival.

Results: Fifty-two (5.7%) cases of MDR-TB were identified, among which eight (15.3%) were diagnosed as XDR-TB on the basis of drug susceptibility testing, using the prescribed definition. The cases were sensitive to 2, 3, 4, 5 and more than 5 drugs in almost equal proportions. Thirty-seven (71.1%) cases were successfully cured; eleven (21.1%) patients died; and only four (7.6%) cases defaulted, indicating overall satisfactory adherence to treatment.

Conclusion: For effective treatment of MDR-TB and XDR-TB, early case detection, improved laboratory facilities, availability of appropriate treatment regimens, and financial assistance in resource-limited settings through effective political intervention are necessary for better patient adherence and overall cure.

Author Biographies

Bikram Singh Datta, Government Medical College associated Chest Diseases Hospital, Srinagar, Kashmir
Government Medical College associated Chest Diseases Hospital, Srinagar, Kashmir, India
Ghulam Hassan, Department of Medicine, Government Medical College associated SMHS Hospital, Srinagar, Kashmir

 

  Department of Medicine, Government Medical College associated SMHS Hospital, Srinagar, Kashmir, India

Syed Manzoor Kadri, Regional Institute of Health and FW, DHS, Srinagar, Kashmir
Regional Institute of Health and FW, DHS, Srinagar, Kashmir, India,
Waseem Qureshi, Government Medical College associated SMHS Hospital, Srinagar, Kashmir
Government Medical College associated SMHS Hospital, Srinagar, Kashmir, India
Mustadiq Ahmad Kamili, Department of Medicine, Government Medical College associated SMHS Hospital, Srinagar, Kashmir
Department of Medicine, Government Medical College associated SMHS Hospital, Srinagar, Kashmir, India
Hardeep Singh, Department of Medicine, Government Medical College associated SMHS Hospital, Srinagar, Kashmir
Department of Medicine, Government Medical College associated SMHS Hospital, Srinagar, Kashmir, India
Ahmad Manzoor, Department of Medicine, Government Medical College associated SMHS Hospital, Srinagar, Kashmir
Department of Medicine, Government Medical College associated SMHS Hospital, Srinagar, Kashmir, India
Mushtaq Ahmad Wani, Department of Medicine, Government Medical College associated SMHS Hospital, Srinagar, Kashmir
Department of Medicine, Government Medical College associated SMHS Hospital, Srinagar, Kashmir, India
Shamas u Din, Department of Chest Medicine, Government Medical College and associated Chest Diseases Hospital, Srinagar, Kashmir
Department of Chest Medicine, Government Medical College and associated Chest Diseases Hospital, Srinagar, Kashmir, India
Natasha Thakur, Department of Surgery , Sheri Kashmir Institute of Medical Sciences , Kashmir
Department of Surgery , Sheri Kashmir Institute of Medical Sciences , Kashmir,India
Published
2009-11-21
How to Cite
1.
Datta BS, Hassan G, Kadri SM, Qureshi W, Kamili MA, Singh H, Manzoor A, Wani MA, Din S u, Thakur N (2009) Multidrug-Resistant and Extensively Drug Resistant Tuberculosis in Kashmir, India. J Infect Dev Ctries 4:019-023. doi: 10.3855/jidc.669
Section
Original Articles