Efficacy and safety of lamivudine treatment in late pregnancy with high HBV DNA: a perspective for mother and infants

  • Sükran Köse Tepecik Training and Research Hospital, Department of Infectious Diseases and Clinic Microbiology, Turkey
  • Melda Türken Tepecik Training and Research Hospital, Department of Infectious Diseases and Clinic Microbiology, Turkey
  • İlker Devrim Pediatric Infectious Disease Unit
  • Cüneyt Taner izmir Aegean Obstetrics and Gynecology Teaching Hospital, Izmir, Turkey
Keywords: lamivudine, chronic hepatitis B infection, pregnancy

Abstract

Introduction: Perinatal transmission - from mother to fetus - is one of the main transmission routes of chronic hepatitis B (CHB) infection. Lamivudine therapy has been reported to prevent the replication of hepatitis B virus (HBV) in pregnant women with a high viral load that can lead to perinatal transmission.

Methodology: This study sought to evaluate retrospectively the efficacy and safety of lamivudine treatment in pregnant women with CHB and a high viral load. Biochemical parameters, and virological and serological responses at the 32nd and 36th week of gestation and after labor were recorded. The complications of CHB and the adverse effects of lamivudine treatment were also recorded.

Results: Following 8 weeks of lamivudine treatment, HBV viral load decreased to levels ≤ 10,000 copies/ml in five of the seven patients (71%) and in three patients (43%), HBV DNA was found to be completely negative after labor. Neither adverse effects caused by lamivudine treatment nor complications due to CHB infection were experienced by mothers or infants.

Conclusions: The results of this study suggest that lamivudine therapy in highly viremic hepatitis B surface antigen (HBsAg)-positive pregnant women could decrease perinatal transmission rates of HBV, and can lower the HBV viral load during labor.

Author Biographies

Sükran Köse, Tepecik Training and Research Hospital, Department of Infectious Diseases and Clinic Microbiology, Turkey
Department of Infectious Tepecik Training and Research Hospital, Department of Infectious Diseases and Clinic Microbiology
Melda Türken, Tepecik Training and Research Hospital, Department of Infectious Diseases and Clinic Microbiology, Turkey
Department of Infectious Tepecik Training and Research Hospital, Department of Infectious Diseases and Clinic Microbiology
İlker Devrim, Pediatric Infectious Disease Unit
Pediatric Infectious Disease Unit, Dr. Behcet Uz Children's Hospital
Cüneyt Taner, izmir Aegean Obstetrics and Gynecology Teaching Hospital, Izmir, Turkey

Izmir Aegean Obstetrics and Gynecology Teaching Hospital, Izmir, Turkey

Published
2011-03-04
How to Cite
1.
Köse S, Türken M, Devrim İlker, Taner C (2011) Efficacy and safety of lamivudine treatment in late pregnancy with high HBV DNA: a perspective for mother and infants. J Infect Dev Ctries 5:303-306. doi: 10.3855/jidc.1398
Section
Brief Original Articles