Seroprevalence of rubella and immunogenicity following rubella vaccination in adolescent girls in India

  • Hitt J Sharma Serum Institute of India Ltd., Pune-411028, India
  • Vasant S Padbidri King Edward Memorial Hospital Research Centre, Pune-411011, India
  • Subhash V Kapre Serum Institute of India Ltd., Pune-411028, India
  • Suresh S Jadhav Serum Institute of India Ltd., Pune-411028, India
  • Rajeev M Dhere Serum Institute of India Ltd., Pune-411028, India
  • Sameer S Parekh Serum Institute of India Ltd., Pune-411028, India
  • Ashok D Dudhane King Edward Memorial Hospital Research Centre, Pune-411011, India
  • Sunil D Shewale Serum Institute of India Ltd., Pune-411028, India
  • Gajanan S Namjoshi Earlier with Serum Institute of India Ltd., Pune-411028, India

Abstract

Introduction: Serologic surveys conducted in different countries indicate that rubella is a worldwide infection.Several such sero surveys conducted in India have also confirmed that 6-47% of women are susceptible to rubella infection. The current study was conducted on 1,329 female adolescents in 12 districts of Maharashtra, India, to assess their serological status in terms of rubella exposure.

Methodology: After enrollment, a pre-vaccination blood sample was collected from the participants followed by rubella vaccination (R-vac). Adverse events were monitored for the next 6-8 weeks, at which time a post-vaccination sample was collected.

Results: Pre-vaccination rubella immunity was higher in the urban (80.2%) population compared to the rural (73.1%) population. Following R-vac vaccination, out of 1,159 participants who completed the study, all (100%) in the urban and 99.5% of participants in the rural area developed antibodies against rubella.

Conclusion: Substantial numbers of women reach childbearing age without immunity against rubella and thus are at a risk of passing the infection to their fetuses, who can then develop subsequent congenital defects leading to congenital rubella syndrome (CRS). An immunization policy recommending vaccination with rubella or rubella containing vaccine is highly desirable to prevent rubella and CRS. 

Author Biographies

Hitt J Sharma, Serum Institute of India Ltd., Pune-411028, India
Deputy Medical Director, Medical Affairs Department, Serum Institute of India ltd., Pune
Vasant S Padbidri, King Edward Memorial Hospital Research Centre, Pune-411011, India
Director, KEM Hospital and Research Centre, Pune
Subhash V Kapre, Serum Institute of India Ltd., Pune-411028, India
Executive Director, Research and Development, Serum Institute of India ltd., Pune
Suresh S Jadhav, Serum Institute of India Ltd., Pune-411028, India
Executive Director, Regulatory Affairs, Serum Institute of India ltd., Pune
Rajeev M Dhere, Serum Institute of India Ltd., Pune-411028, India
Senior Director, MMR Production department, Serum Institute of India ltd., Pune
Sameer S Parekh, Serum Institute of India Ltd., Pune-411028, India
Manager, Medical affairs Department, Serum Institute of India ltd., Pune
Ashok D Dudhane, King Edward Memorial Hospital Research Centre, Pune-411011, India
Research Officer, KEM Hospital and Research Centre, Pune
Sunil D Shewale, Serum Institute of India Ltd., Pune-411028, India
Clinical Research Associate, Medical affairs Department, Serum Institute of India ltd., Pune
Gajanan S Namjoshi, Earlier with Serum Institute of India Ltd., Pune-411028, India
Assistant Director, Serum Institute of India ltd., Pune
Published
2011-11-08
How to Cite
Sharma H, Padbidri V, Kapre S, Jadhav S, Dhere R, Parekh S, Dudhane A, Shewale S, Namjoshi G (2011) Seroprevalence of rubella and immunogenicity following rubella vaccination in adolescent girls in India. The Journal Of Infection In Developing Countries 5 (12): 874-881. https://doi.org/10.3855/jidc.1847
Section
Original Articles

Keywords

rubella; serological survey; immunogenicity; safety