A case report and review of the literature: Ciprofloxacin resistant Salmonella enterica serovar Typhi in India

  • Belgode Narasimha Harish Department of Microbiology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry
  • Godfred Antony Menezes Department of Microbiology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry
  • Kengamuthu Sarangapani Department of Microbiology, Government General Hospital, Pondicherry
  • Subhash Chandra Parija Department of Microbiology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry

Abstract

Background: Enteric fever is a major public health problem in India. The current treatment of choice is the fluoroquinolones.
Methods: The minimum inhibitory concentration (MIC) of ciprofloxacin was determined by E-test, HIMEDIA HiComb MIC test and agar dilution.
Results: An isolate of Salmonella enterica serovar Typhi (S. Typhi) from a case of enteric fever gave a ciprofloxacin MIC of 64μg/ml.
Conclusions: To our knowledge there have been no reports of such high-level resistance to ciprofloxacin in S. Typhi from southern India. HIMEDIA HiComb MIC test method is an alternative to the E-test. Ciprofloxacin resistant typhoid fever responds to treatment with ceftriaxone.
Published
2008-08-01
How to Cite
Harish B, Menezes G, Sarangapani K, Parija S (2008) A case report and review of the literature: Ciprofloxacin resistant Salmonella enterica serovar Typhi in India. The Journal Of Infection In Developing Countries 2 (04): 324-327. https://doi.org/10.3855/jidc.229
Section
Case Reports

Keywords

Enteric fever, Salmonella Typhi, drug resistance