Risk factors for bacteremia due to extended-spectrum beta-lactamase-producing Escherichia coli in a Turkish hospital

Onur Kaya; Fusun Zeynep Akcam; Ibak Gonen; Onur Unal; Tennure Ceylan

doi:10.3855/jidc.2788

Risk factors for bacteremia due to extended-spectrum beta-lactamase-producing Escherichia coli in a Turkish hospital

Authors

Onur Kaya Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey
Fusun Zeynep Akcam Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey
Ibak Gonen Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey
Onur Unal Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey
Tennure Ceylan Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey

DOI:

https://doi.org/10.3855/jidc.2788

Keywords:

risk factors, Escherichia coli, bacteremia, extended-spectrum beta-lactamase

Abstract

Introduction: Bloodstream infection caused by extended-spectrum beta-lactamase (ESBL)-producing pathogens has become a serious concern worldwide. The purpose of this study was to identify risk factors for bacteremia due to ESBL-producing Escherichia coli in a Turkish hospital.

Methodology: We retrospectively reviewed the medical records of patients with E. coli bacteremia in a tertiary care centre from January 2007 to October 2011. Data from patients such as demographic features, underlying conditions, and antibiotic exposure were analysed.

Results: A total of 113 patients with bacteremia due to E. coli were included and data from patients with ESBL-producing E. coli (case patients) were compared to those with non-ESBL-producing E. coli (control patients). The frequency of ESBL producers was 38.9% (44/113). Exposure to fluoroquinolones and cephalosporins, history of intra-abdominal surgery intervention, and presence of central venous catheteter and urinary catheteter were more frequently detected among case patients (P < 0.05). Independent risk factors for bacteremia due to ESBL-producing E. coli were exposure to fluoroquinolones (OR 13.39, 95% CI 1.28-140.03) and cephalosporins (OR 3.48, 95% CI 1.03-11.74).

Conclusions: Previous use of fluoroquinolone and cephalosporin in patients with bacteremia caused by E. coli increased the risk for ESBL-producing strains.

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Published

2013-07-15

How to Cite

Kaya O, Akcam FZ, Gonen I, Unal O, Ceylan T (2013) Risk factors for bacteremia due to extended-spectrum beta-lactamase-producing Escherichia coli in a Turkish hospital. J Infect Dev Ctries 7:507–512. doi: 10.3855/jidc.2788

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Issue

Vol. 7 No. 07: July 2013

Section

Original Articles

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