Etiological diversity of diarrhoeal disease in Bangladesh

Authors

  • Sumon Kumar Das International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
  • Shahnawaz Ahmed International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
  • Farzana Ferdous International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
  • Fahmida Dil Farzana International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
  • Mohammod Jobayer Chisti International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
  • Jonathan Ross Latham London School of Hygiene and Tropical Medicine, London, United Kingdom
  • Kaisar Ali Talukder International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
  • Mustafizur Rahman International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
  • Yasmin Ara Begum International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
  • Firdausi Qadri International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
  • Abu Syed Golam Faruque International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
  • Tahmeed Ahmed International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh

DOI:

https://doi.org/10.3855/jidc.3003

Keywords:

antimicrobial resistance, diarrhoea, etiology, rural, susceptible, urban

Abstract

Background: This study compared the diversity of common diarrhoeal pathogens and antimicrobial susceptibility in four hospitals in Bangladesh.

Methodology: A total of 13,959 diarrhoea patients, comprising rural Mirzapur [2,820), rural Matlab (2,865), urban Dhaka (5,287) and urban Mirpur (2,987) were included under the diarrhoeal disease surveillance system of icddr,b during 2010-2011; stool specimens were tested for Shigella spp., Vibrio cholerae, enterotoxigenic Escherichia coli and rotavirus.

Results: Rotavirus was highest in Mirzapur (28%) followed by Dhaka (24%), Matlab (19%) and Mirpur (18%). Overall, Shigella was significantly more prevalent in rural sites (Mirzapur 13% and Matlab 7%), than in urban sites (Dhaka 3% and Mirpur 3%). Vibrio cholerae was more common in the urban sites of Dhaka (14%) and Mirpur (12%). 72% of Shigella isolates were susceptible to ciprofloxacin in Mirzapur, and 88% to mecillinam. In Dhaka, the figures for Shigella were 65% and 50%, in Matlab 65% and 85%, and in Mirpur 59% and 92% respectively. Susceptibility of Shigella to azithromycin and ceftriaxone in Dhaka was 74% and 95%, and in Mirpur 88% and 92% respectively.  Vibrio cholerae showed the highest resistance to trimethoprim-sulfamethoxazole (100% in Mirpur) and lowest resistance to ciprofloxacin (0% in Dhaka, Matlab and Mirpur) and azithromycin (30% in Dhaka to 7% in Mirzapur). Multidrug resistance (≥ 3 antibiotics) for Shigella were: Mirzapur (50%); Dhaka (36%); Matlab (23%) and Mirpur (37%); and for V. cholerae it was 26%, 37%, 49% and 23% respectively.

Conclusion: The isolation rates and antimicrobial susceptibility of Shigella spp. and V. cholerae along with rotavirus differed significantly in certain geographical sites.

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Author Biographies

Sumon Kumar Das, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh

Medical Officer, Centre for Nutrition and Food Securityy

Shahnawaz Ahmed, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh

Medical Officer, Centre for Nutrition and Food Security

Farzana Ferdous, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh

Centre for Nutrition and Food Security

Fahmida Dil Farzana, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh

Centre for Nutrition and Food Security

Mohammod Jobayer Chisti, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh

Associate Scientist, Centre for Nutrition and Food Security

Kaisar Ali Talukder, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh

Senior Scientist, Centre for Food and Water Born Disease

Mustafizur Rahman, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh

Associate Scientist, Centre for Communicable Disease

Yasmin Ara Begum, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh

Deputy Project Coordinator, Enteric Vaccines

Firdausi Qadri, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh

Director, Centre for Vaccine Sciences

Abu Syed Golam Faruque, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh

Consultant, Centre for Nutrition and Food Security

Tahmeed Ahmed, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh

Director, Centre for Nutrition and Food Security

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Published

2013-12-15

How to Cite

1.
Das SK, Ahmed S, Ferdous F, Farzana FD, Chisti MJ, Latham JR, Talukder KA, Rahman M, Begum YA, Qadri F, Faruque ASG, Ahmed T (2013) Etiological diversity of diarrhoeal disease in Bangladesh. J Infect Dev Ctries 7:900–909. doi: 10.3855/jidc.3003

Issue

Section

Emerging Problems in Infectious Diseases

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