Immune response to influenza A(H1N1)v in HIV-infected patients

  • Paola Sansonetti Catholic University of Sacred Heart, Rome, Italy
  • Michela Sali Catholic University of Sacred Heart, Rome, Italy
  • Massimiliano Fabbiani Catholic University of Sacred Heart, Rome, Italy
  • Matteo Morandi Catholic University of Sacred Heart, Rome, Italy
  • Rosa Martucci Catholic University of Sacred Heart, Rome, Italy
  • Ali Danesh International Institute of Infection and Immunity, Shantou University Medical College, Shantou, Guangdong, China
  • Giovanni Delogu Catholic University of Sacred Heart, Rome, Italy
  • Jesus Bermejo-Martin Infection and Immunity Medical Investigation Unit (IMI), Microbiology and Immunology Service, Hospital Clínico Universitario-IECSCYL, Valladolid, Spain
  • Maurizio Sanguinetti Catholic University of Sacred Heart, Rome, Italy
  • David Kelvin International Institute of Infection and Immunity, Shantou University Medical College, Shantou, Guangdong, China
  • Roberto Cauda Catholic University of Sacred Heart, Rome, Italy
  • Giovanni Fadda Catholic University of Sacred Heart, Rome, Italy
  • Salvatore Rubino University of Sassari, Sassari, Italy
Keywords: HIV, influenza A(H1N1)v 2009, cytokines, chemokines, antibody response

Abstract

Introduction: HIV infection is considered a risk factor for severe outcomes of influenza A(H1N1)v infection. However, data on immune response against influenza A(H1N1)v virus in HIV-infected patients are lacking.

Methodology: Data from seven HIV-positive and 14 HIV-negative patients infected with A(H1N1)v and from 23 HIV-positive and six HIV-negative asymptomatic controls were analyzed to evaluate the clinical picture, A(H1N1)v viral shedding, and the immune response against the virus.

Results: Patients displayed mainly upper respiratory tract diseases (57.1%), while pneumonia was diagnosed only in HIV-negative patients (23.8% of subjects, of which 4.8% required intensive care unit admission). At day seven, 29% of HIV-infected patients were still positive for A(H1N1)v by RT-PCR on nasopharyngeal swabs. Interestingly, a persistence of CXCL10 secretion at high level and lower IL-6 levels was observed in HIV-positive subjects. The geometric mean haemagglutination inhibition titer (HI-GMT) and anti-influenza IgM levels were lower in HIV-positive individuals while anti-influenza IgG levels remained similar in the two groups.

Conclusions: The immune impairment due to HIV infection could affect A(H1N1)v clearance and could lead to a lower antibody response and a persistent secretion of CXCL10 at high levels. However, the lower IL-6 secretion and treatment with highly active antiretroviral therapy (HAART) could result in a milder clinical picture.

Author Biography

Michela Sali, Catholic University of Sacred Heart, Rome, Italy

Institute of Microbiology

Published
2014-01-15
How to Cite
1.
Sansonetti P, Sali M, Fabbiani M, Morandi M, Martucci R, Danesh A, Delogu G, Bermejo-Martin J, Sanguinetti M, Kelvin D, Cauda R, Fadda G, Rubino S (2014) Immune response to influenza A(H1N1)v in HIV-infected patients. J Infect Dev Ctries 8:101-109. doi: 10.3855/jidc.3147
Section
Original Articles