Detection of the novel IMP-38 among carbapenemase-producing Enterobacteriaceae in a university hospital, China

Authors

  • Zijuan Jian Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, P. R. China.
  • Yanming Li Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, P. R. China.
  • Wenen Liu Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, P.R. China
  • Hongling Li Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, P. R. China.
  • Yunli Zhang Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, P. R. China.
  • Yanbing Li Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, P. R. China.
  • Xiumei Gu Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, P. R. China.
  • Wanchan Peng Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, P. R. China.

DOI:

https://doi.org/10.3855/jidc.4179

Keywords:

carbapenemase, Enterobacteriaceae, IMP, KPC

Abstract

Introduction: This study set out to investigate the molecular epidemiology of carbapenemase-producing Enterobacteriaceae isolates collected from Xiang Ya Hospital, Hunan, China.

Methodology: The carbapenemase genes from Enterobacteriaceae isolates were determined by PCR and sequencing. Relatedness of Klebsiella pneumoniae isolates was evaluated by pulsed-field gel electrophoresis.

Results: Twenty-four out of 738 non-repetitive Enterobacteriaceae isolates harbored carbapenemase genes including IMP-38, a novel IMP-type metallo-enzyme. Nine IMP-38-producing isolates were shown to originate from the same clone and caused a small outbreak in the neonatal ward.

Conclusions: IMP-38, a novel IMP-type metallo-enzyme, was one of the predominant types of carbapenemase in the clinical carbapenem-resistant Enterobacteriaceae isolates in our hospital.

👁 Abstract Views: 1,191📥 PDF Downloads: 1,191

Author Biography

Wenen Liu, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, P.R. China

M.D., Ph.D.

Director of Clinical Laboratory, Xiangya Hospital

Downloads

Published

2014-08-13

How to Cite

1.
Jian Z, Li Y, Liu W, Li H, Zhang Y, Li Y, Gu X, Peng W (2014) Detection of the novel IMP-38 among carbapenemase-producing Enterobacteriaceae in a university hospital, China. J Infect Dev Ctries 8:1044–1048. doi: 10.3855/jidc.4179

Issue

Vol. 8 No. 08: August 2014

Section

Brief Original Articles

License

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
Crossref
Scopus
Google Scholar
Europe PMC