Detection of the novel IMP-38 among carbapenemase-producing Enterobacteriaceae in a university hospital, China

  • Zijuan Jian Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, P. R. China.
  • Yanming Li Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, P. R. China.
  • Wenen Liu Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, P.R. China
  • Hongling Li Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, P. R. China.
  • Yunli Zhang Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, P. R. China.
  • Yanbing Li Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, P. R. China.
  • Xiumei Gu Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, P. R. China.
  • Wanchan Peng Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, P. R. China.
Keywords: carbapenemase, Enterobacteriaceae, IMP, KPC

Abstract

Introduction: This study set out to investigate the molecular epidemiology of carbapenemase-producing Enterobacteriaceae isolates collected from Xiang Ya Hospital, Hunan, China.

Methodology: The carbapenemase genes from Enterobacteriaceae isolates were determined by PCR and sequencing. Relatedness of Klebsiella pneumoniae isolates was evaluated by pulsed-field gel electrophoresis.

Results: Twenty-four out of 738 non-repetitive Enterobacteriaceae isolates harbored carbapenemase genes including IMP-38, a novel IMP-type metallo-enzyme. Nine IMP-38-producing isolates were shown to originate from the same clone and caused a small outbreak in the neonatal ward.

Conclusions: IMP-38, a novel IMP-type metallo-enzyme, was one of the predominant types of carbapenemase in the clinical carbapenem-resistant Enterobacteriaceae isolates in our hospital.

Author Biography

Wenen Liu, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, P.R. China

M.D., Ph.D.

Director of Clinical Laboratory, Xiangya Hospital

Published
2014-08-13
How to Cite
1.
Jian Z, Li Y, Liu W, Li H, Zhang Y, Li Y, Gu X, Peng W (2014) Detection of the novel IMP-38 among carbapenemase-producing Enterobacteriaceae in a university hospital, China. J Infect Dev Ctries 8:1044-1048. doi: 10.3855/jidc.4179
Section
Brief Original Articles