Seroprevalence of hepatitis A,B, and C viruses in Turkish alcoholic cirrhotics and the impact of hepatitis B on clinical profile

  • Fatih Tekin Ege University Medical School, Izmir, Turkey
  • Fulya Gunsar Ege University Medical School, Izmir, Turkey
  • Elvan Isik Erdogan Ege University Medical School, Izmir, Turkey
  • Ruchan Yazan Sertoz Ege University Medical School, Izmir, Turkey
  • Zeki Karasu Ege University Medical School, Izmir, Turkey
  • Galip Ersoz Ege University Medical School, Izmir, Turkey
  • Omer Ozutemiz Ege University Medical School, Izmir, Turkey
  • Ulus Akarca Ege University Medical School, Izmir, Turkey
Keywords: alcoholic cirrhosis, viral hepatitis, seroprevalence, Turkey

Abstract

Introduction: The aims of this study were to detect the seroprevalence of hepatitis A, B, and C viruses in Turkish alcoholic cirrhotics, and to evaluate the impact of hepatitis B infection on clinical profile at first admittance.

Methodology: Serological markers for hepatitis A, B, and C viruses in 300 alcoholic cirrhotics diagnosed between January 1994 and December 2012 were retrospectively reviewed. Among them, 148 eligible patients were divided into group 1 (HBsAg positive, n = 43) and group 2 (HBsAg and anti-HBc negative, n = 105). Clinical characteristics at first admittance of groups 1 and 2 were compared.

Results: The seroprevalence of anti-HAV total, HBsAg, and anti-HCV was found to be 91.5%, 16.3%, and 8.2%, respectively. The prevalence of hepatocellular carcinoma was higher in the HbsAg-positive group compared to HbsAg- and anti-HBc-negative group (16.3% vs. 2.9%, p = 0.007). Other clinical features were similar in the two groups.

Conclusions: Alcoholic cirrhotics have higher frequencies of HBsAg and anti-HCV than the general population. These patients should be investigated for coexistent HBV and HCV infections, and HBV vaccination should not be neglected. Alcoholic cirrhotic patients with concomitant HBV infection should be closely screened for hepatocellular carcinoma.

Author Biographies

Fatih Tekin, Ege University Medical School, Izmir, Turkey
Department of Gastroenterology
Fulya Gunsar, Ege University Medical School, Izmir, Turkey
Department of Gastroenterology
Elvan Isik Erdogan, Ege University Medical School, Izmir, Turkey
Department of Gastroenterology
Ruchan Yazan Sertoz, Ege University Medical School, Izmir, Turkey
Department of Clinical Microbiology
Zeki Karasu, Ege University Medical School, Izmir, Turkey
Department of Gastroenterology
Galip Ersoz, Ege University Medical School, Izmir, Turkey
Department of Gastroenterology
Omer Ozutemiz, Ege University Medical School, Izmir, Turkey
Department of Gastroenterology
Ulus Akarca, Ege University Medical School, Izmir, Turkey
Department of Gastroenterology
Published
2015-03-15
How to Cite
1.
Tekin F, Gunsar F, Erdogan EI, Sertoz RY, Karasu Z, Ersoz G, Ozutemiz O, Akarca U (2015) Seroprevalence of hepatitis A,B, and C viruses in Turkish alcoholic cirrhotics and the impact of hepatitis B on clinical profile. J Infect Dev Ctries 9:254-258. doi: 10.3855/jidc.6002
Section
Original Articles