Itraconazole-resistant Candida auris with phospholipase, proteinase and hemolysin activity from a case of vulvovaginitis

Dharmendra Kumar; Tuhina Banerjee; Chandra Bhan Pratap; Ragini Tilak

doi:10.3855/jidc.4582

Itraconazole-resistant Candida auris with phospholipase, proteinase and hemolysin activity from a case of vulvovaginitis

Authors

Dharmendra Kumar Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
Tuhina Banerjee Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
Chandra Bhan Pratap Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
Ragini Tilak Institute of Medical Sciences, Banaras Hindu University, Varanasi, India

DOI:

https://doi.org/10.3855/jidc.4582

Keywords:

C. auris, non-albicans, resistance, phospholipase

Abstract

Since the emergence of pathogenic non-albicans Candida species, a number of new isolates have been added to the list. One such unusual species is Candida auris (C. auris), recently isolated and studied in few reports. In this study, a case of vulvovaginitis caused by Candida auris incidentally identified by molecular methods using internal transcribed spacer polymerase chain reaction (ITS PCR) is described. Antifungal susceptibility testing revealed the isolate to be resistant to itraconazole (MIC ≥ 2 µg/ml) and expressed important virulence factors including phospholipase, proteinase and hemolysin activity. The patient was successfully treated with oral fluconazole and did not have any invasive fungemia.

Very few cases of this emerging pathogen have been reported. However, its isolation from clinical specimens reveals the significance of non-albicans candida species over C. albicans and the diversity of Candida spp causing infections.

Author Biography

Dharmendra Kumar, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India

Research Scholar

Department of Microbiology

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Published

2015-04-15

How to Cite

Kumar D, Banerjee T, Pratap CB, Tilak R (2015) Itraconazole-resistant Candida auris with phospholipase, proteinase and hemolysin activity from a case of vulvovaginitis. J Infect Dev Ctries 9:435–437. doi: 10.3855/jidc.4582

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Issue

Vol. 9 No. 04: April 2015

Section

Case Reports

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