Itraconazole-resistant Candida auris with phospholipase, proteinase and hemolysin activity from a case of vulvovaginitis

  • Dharmendra Kumar Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
  • Tuhina Banerjee Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
  • Chandra Bhan Pratap Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
  • Ragini Tilak Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
Keywords: C. auris, non-albicans, resistance, phospholipase

Abstract

Since the emergence of pathogenic non-albicans Candida species, a number of new isolates have been added to the list. One such unusual species is Candida auris (C. auris), recently isolated and studied in few reports. In this study, a case of vulvovaginitis caused by Candida auris incidentally identified by molecular methods using internal transcribed spacer polymerase chain reaction (ITS PCR) is described. Antifungal susceptibility testing revealed the isolate to be resistant to itraconazole (MIC ≥ 2 µg/ml) and expressed important virulence factors including phospholipase, proteinase and hemolysin activity. The patient was successfully treated with oral fluconazole and did not have any invasive fungemia.

Very few cases of this emerging pathogen have been reported. However, its isolation from clinical specimens reveals the significance of non-albicans candida species over C. albicans and the diversity of Candida spp causing infections.

Author Biography

Dharmendra Kumar, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India

Research Scholar

Department of Microbiology

Published
2015-04-15
How to Cite
1.
Kumar D, Banerjee T, Pratap CB, Tilak R (2015) Itraconazole-resistant Candida auris with phospholipase, proteinase and hemolysin activity from a case of vulvovaginitis. J Infect Dev Ctries 9:435-437. doi: 10.3855/jidc.4582
Section
Case Reports