Seroepidemiology of hepatitis B virus infection among Chinese schizophrenia patients

  • Huijuan Zhu School of Public Health, Jiangsu Key Laboratory and Translational Medicine for Geriatric Disease, Medical College of Soochow University, Suzhou, Jiangsu, China
  • Xingxiang Liu Huai’an Fourth Hospital, Huai’an, China
  • Yong Xue Huai’an Third Hospital, Huai’an, China
  • Chong Shen School of Public Health, Nanjing Medical University, Nanjing, China
  • Yinghui Li Huai’an Third Hospital, Huai’an, China
  • Aili Wang School of Public Health, Jiangsu Key Laboratory and Translational Medicine for Geriatric Disease, Medical College of Soochow University, Suzhou, Jiangsu, China
  • Yi Ding Suzhou Industrial Park Centers for Disease Control and Prevention, Suzhou, China
  • Zhi Zheng Huai’an Third Hospital, Huai’an, China
  • Chen Dong School of Public Health, Jiangsu Key Laboratory and Translational Medicine for Geriatric Disease, Medical College of Soochow University, Suzhou, Jiangsu, China
Keywords: schizophrenia, hepatitis B, HBsAg, genotype

Abstract

Introduction: This study aimed to analyze the characteristics of HBsAg, HBsAb, coexistence of HBsAg and HBsAb, and the genotypic distribution of HBV in Chinese schizophrenia patients.

Methodology: A total of 1,694 schizophrenia patients, 9-85 years of age, were recruited for the present study. HBsAg, HBsAb, and HBV DNA were detected with commercial methods. ALT, AST, γ-GT, TBIL, and IBIL were measured by an automatic biochemistry analyzer. All statistical analyses were performed with SPSS 13.0.

Results: The seroprevalence of HBsAg and HBsAb in 1,649 schizophrenia patients was 11.0% and 54.6%, respectively. HBsAb seroprevalence significantly decreased with the duration of the disease (p = 0.0009). The lowest seroprevalence of HBsAg was determined in 9.4% of the patients who had had the illness for < 1 year, and then increased to 11.7%, 11.3% and 11.7% in the patients who had had the illness for 1–5 years, 6–10 years and > 10 years. HBsAg and HBsAb coexisted in 69 individuals, which comprised 4.2% of the total subjects, and in 38.1% of the HBsAg-positive patients. Additionally, HBV titers were quantified in 64 HBsAg-positive samples; the highest virus titer was 6.14×108 copies/mL, while 12 patients had less than 500 copies/mL. Moreover, among 48 HBV strains isolated from 62 HBsAg-positive samples, 33 and 15 strains belonged to genotypes C and B, respectively.

Conclusion: Genotypes B and C HBV were the dominant genotypes distributed in schizophrenia patients, and the HBsAb seroprevalence significantly decreased with illness duration. Effective prevention strategies for against HBV transmission are required.

Author Biographies

Huijuan Zhu, School of Public Health, Jiangsu Key Laboratory and Translational Medicine for Geriatric Disease, Medical College of Soochow University, Suzhou, Jiangsu, China

Department of Epidemiology and Biostatistics, School of Public Health

Chong Shen, School of Public Health, Nanjing Medical University, Nanjing, China
Department of Epidemiology and Biostatistics, School of Public Health
Aili Wang, School of Public Health, Jiangsu Key Laboratory and Translational Medicine for Geriatric Disease, Medical College of Soochow University, Suzhou, Jiangsu, China

Department of Epidemiology and Biostatistics, School of Public Health

Chen Dong, School of Public Health, Jiangsu Key Laboratory and Translational Medicine for Geriatric Disease, Medical College of Soochow University, Suzhou, Jiangsu, China

Associate Professor

Department of Epidemiology and Biostatistics, School of Public Health

Published
2015-05-18
How to Cite
1.
Zhu H, Liu X, Xue Y, Shen C, Li Y, Wang A, Ding Y, Zheng Z, Dong C (2015) Seroepidemiology of hepatitis B virus infection among Chinese schizophrenia patients. J Infect Dev Ctries 9:512-518. doi: 10.3855/jidc.5416
Section
Original Articles