Prevalence of cagA and vacA among Helicobacter pylori-infected patients in Iran: a systematic review and meta-analysis

  • Fatemeh Sayehmiri Student Research Committee, Ilam University of Medical Sciences, Ilam, Iran
  • Faezeh Kiani Student Research Committee, Ilam University of Medical Sciences, Ilam, Iran
  • Kourosh Sayehmiri Prevention of Psychosocial Injuries Research Center, Ilam University of Medical Sciences, Ilam, Iran
  • Setareh Soroush Clinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam, Iran
  • Khairollah Asadollahi Prevention of Psychosocial Injuries Research Center, Ilam University of Medical Sciences, Ilam, Iran
  • Mohammad Yousef Alikhani School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
  • Ali Delpisheh Prevention of Psychosocial Injuries Research Center, Ilam University of Medical Sciences, Ilam, Iran
  • Mohammad Emaneini School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  • Lidija Bogdanovic University of Naples Federico II, Naples, Italy
  • Ali Mohammad Varzi School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
  • Raffaele Zarrilli University of Naples Federico II, Naples, Italy
  • Morovat Taherikalani School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
Keywords: cagA, vacA, prevalence, H. pylori, meta-analysis, Iran

Abstract

The varieties of infections caused by Helicobacter pylori may be due to differences in bacterial genotypes and virulence factors as well as environmental and host-related factors. This study aimed to investigate the prevalence of cagA and vacA genes among H. pylori-infected patients in Iran and analyze their relevance to the disease status between two clinical groups via a meta-analysis method.

Different databases including PubMed, ISI, Scopus, SID, Magiran, Science Direct, and Medlib were investigated, and 23 relevant articles from the period between 2001 and 2012 were finally analyzed. The relevant data obtained from these papers were analyzed by a random-effects model. Data were analyzed using R software and STATA. The prevalence of cagA and vacA genes among H. pylori-infected patients was 70% (95% CI, 64–75) and 41% (95% CI, 24.3–57.7), respectively. The prevalence of duodenal ulcers, peptic ulcers, and gastritis among cagA+ individuals was 53% (95% CI, 20–86), 65% (95% CI, 34–97), and 71% (95% CI, 59–84), respectively. Odds ratio (OR) between cagA-positive compared with cagA-negative patients showed a 1.89 (95% CI, 1.38–2.57) risk of ulcers. In conclusion, the frequency of cagA gene among H. pylori strains is elevated in Iran and it seems to be more frequently associated with gastritis. Therefore, any information about cagA and vacA prevalence among different H. pylori-infected clinical groups in the country can help public health authorities to plan preventive policies to reduce the prevalence of diseases associated with H. pylori infection.

Published
2015-07-30
How to Cite
1.
Sayehmiri F, Kiani F, Sayehmiri K, Soroush S, Asadollahi K, Alikhani MY, Delpisheh A, Emaneini M, Bogdanovic L, Varzi AM, Zarrilli R, Taherikalani M (2015) Prevalence of cagA and vacA among Helicobacter pylori-infected patients in Iran: a systematic review and meta-analysis. J Infect Dev Ctries 9:686-696. doi: 10.3855/jidc.5970
Section
Reviews