Enteric fever burden in North Jakarta, Indonesia: a prospective, community-based study

  • Narain H Punjabi U.S. Naval Medical Research Unit No. 2, Jakarta, Indonesia
  • Magdarina D Agtini National Institute of Health Research and Development R.I, Jakarta, Indonesia
  • R. Leon Ochiai International Vaccine Institute, Seoul, Korea
  • Cyrus H Simanjuntak U.S. Naval Medical Research Unit No. 2, Jakarta, Indonesia
  • Murad Lesmana U.S. Naval Medical Research Unit No. 2, Jakarta, Indonesia
  • Decy Subekti U.S. Naval Medical Research Unit No. 2, Jakarta, Indonesia
  • Buhari A Oyofo U.S. Naval Medical Research Unit No. 2, Jakarta, Indonesia
  • Lorenz von Seidlein International Vaccine Institute, Seoul, Korea
  • Jacqueline Deen International Vaccine Institute, Seoul, Korea
  • Seonghye Shin International Vaccine Institute, Seoul, Korea
  • Camilo Acosta International Vaccine Institute, Seoul, Korea
  • Ferry Wangsasaputra National Institute of Health Research and Development R.I, Jakarta, Indonesia
  • Sri P Pulungsih Infectious Diseases Hospital Prof. Dr. Sulianti Saroso, Jakarta, Indonesia
  • Santoso Saroso Infectious Diseases Hospital Prof. Dr. Sulianti Saroso, Jakarta, Indonesia
  • Suyeti Suyeti International Vaccine Institute, Seoul, Korea
  • Suharno R National Institute of Health Research and Development R.I, Jakarta, Indonesia
  • Pratiwi Sudarmono Microbiology Department, University of Indonesia, Jakarta, Indonesia
  • Agus Syarurachman Microbiology Department, University of Indonesia, Jakarta, Indonesia
  • Agus Suwandono National Institute of Health Research and Development R.I, Jakarta, Indonesia
  • Sumarjati Arjoso National Institute of Health Research and Development R.I, Jakarta, Indonesia
  • H. James Beecham III U.S. Naval Medical Research Unit No. 2, Jakarta, Indonesia
  • Andrew L Corwin U.S. Naval Medical Research Unit No. 2, Jakarta, Indonesia
  • John D Clemens International Vaccine Institute, Seoul, Korea
Keywords: enteric fever, typhoid fever, paratyphoid fever, incidence

Abstract

Introduction: We undertook a prospective community-based study in North Jakarta, Indonesia, to determine the incidence, clinical characteristics, seasonality, etiologic agent, and antimicrobial susceptibility pattern of enteric fever.

Methodology: Following a census, treatment centre-based surveillance for febrile illness was conducted for two-years. Clinical data and a blood culture were obtained from each patient.

Results: In a population of 160,261, we detected 296 laboratory-confirmed enteric fever cases during the surveillance period, of which 221 (75%) were typhoid fever and 75 (25%)  were paratyphoid fever.  The overall incidence of typhoid and paratyphoid cases was 1.4, and 0.5 per thousand populations per year, respectively. Although the incidence of febrile episodes evaluated was highest among children under 5 years of age at 92.6 per thousand persons per year, we found that the burden of typhoid fever was greatest among children between 5 and 20 years of age. Paratyphoid fever occurred most commonly in children and was infrequent in adults.

Conclusion: Enteric fever is a public health problem in North Jakarta with a substantial proportion due to paratyphoid fever. The results highlight the need for control strategies against enteric fever.

Published
2013-11-15
How to Cite
1.
Punjabi N, Agtini M, Ochiai RL, Simanjuntak C, Lesmana M, Subekti D, Oyofo B, von Seidlein L, Deen J, Shin S, Acosta C, Wangsasaputra F, Pulungsih S, Saroso S, Suyeti S, R S, Sudarmono P, Syarurachman A, Suwandono A, Arjoso S, Beecham III HJ, Corwin A, Clemens J (2013) Enteric fever burden in North Jakarta, Indonesia: a prospective, community-based study. J Infect Dev Ctries 7:781-787. doi: https://doi.org/10.3855/jidc.2629
Section
Original Articles