Association between Helicobacter pylori infection and overweight or obesity in a Chinese population

  • Yan Zhang Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
  • Tingting Du Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
  • Xi Chen Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
  • Xuefeng Yu Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
  • Ling Tu Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
  • Cuntai Zhang Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
Keywords: Helicobacter pylori infection, body mass index, overweight, obesity

Abstract

Introduction: Recent studies found that Helicobacter pylori (H. pylori) infection plays a role in cardiometabolic disorders. The objective of this study was to assess the association between H. pylori infection and overweight or obesity in a Chinese population.

Methodology: A cross-sectional analysis using data from the subjects who underwent a health examination between January 2010 and June 2012 in the department of comprehensive medicine was performed. Diagnosis of H. pylori infection was achieved using the carbon urea breath test (14C-UBT). The participants were divided into H. pylori infection-positive group and H. pylori infection-negative group by 14C-UBT.

Results: A total of 2,050 subjects were enrolled in the study. The H. pylori infection-positive group had significantly higher body mass index (BMI) levels than did the H. pylori infection-negative group (25.32 vs 24.95, p = 0.008). There was a positive association between H. pylori infection and BMI levels (β = 0.30 ± 0.12, p = 0.015). After additional adjustment for white blood cell count (WBCC), the statistical significance disappeared (β = 0.24 ± 0.12, p = 0.053). Furthermore, a positive association between H. pylori infection and overweight/obesity according to different BMI criteria (BMI ≥ 24, BMI ≥ 23) was found. However, the association between H. pylori infection and obesity was consistently significant only based on the Asian criteria (BMI ≥ 27.5), but not significant based on the Chinese criteria (BMI ≥ 28).

Conclusion: H. pylori infection was significantly and positively associated with overweight/obesity in a Chinese population.

Author Biographies

Yan Zhang, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
Department of Comprehensive Medicine
Tingting Du, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
Department of Endocrinology
Xi Chen, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
Department of Endocrinology
Xuefeng Yu, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
Department of Endocrinology
Ling Tu, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
Department of Comprehensive Medicine
Cuntai Zhang, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
Department of Comprehensive Medicine
Published
2015-09-27
How to Cite
1.
Zhang Y, Du T, Chen X, Yu X, Tu L, Zhang C (2015) Association between Helicobacter pylori infection and overweight or obesity in a Chinese population. J Infect Dev Ctries 9:945-953. doi: 10.3855/jidc.6035
Section
Original Articles