Different features of influenza A H1N1pdm09 virus infection among adults in 2009/10 and 2010/11

  • Svjetlana Grgic University Hospital Mostar, Mostar, Bosnia and Herzegovina
  • Sinisa Skocibusic University Hospital Mostar, Mostar, Bosnia and Herzegovina
  • Elvira Celjuska-Tosev University Hospital for Infectious Diseases Dr. Fran Mihaljevic, Zagreb, Croatia
  • Jadranka Nikolic University Hospital Mostar, Mostar, Bosnia and Herzegovina
  • Jurica Arapovic University Hospital Mostar, Mostar, Bosnia and Herzegovina
  • Ilija Kuzman University of Mostar, Mostar, Bosnia and Herzegovina
Keywords: influenza A virus, H1N1 subtype, risk factors, complications, mortality

Abstract

Introduction: Influenza A H1N1pdm09 virus infection causes an epidemiologically and clinically severe disease mostly characterized by pneumonia, resulting in a high mortality rate. The purpose of this study was to investigate and compare epidemiological and clinical characteristics of influenza A H1N1pdm09 virus infection in patients hospitalized during the pandemic (2009/10) and post-pandemic seasons (2010/11).

Methodology: The data of patients with laboratory-confirmed influenza A H1N1pdm09 virus infection hospitalized and treated at the University Hospital for Infectious Diseases Dr. Fran Mihaljevic in Zagreb, Croatia in the first two seasons of appearance were analyzed.

Results: Compared to the pandemic season, in the post-pandemic season, patients were hospitalized longer, had higher values of inflammatory parameters, and were more often treated with antibiotics. The total number of risk factors in patients did not vary significantly between the two seasons. In the pandemic season, a significantly higher number of obese patients and patients with chronic lung disease was observed, whereas in the post-pandemic season, a statistically significant number of patients presented with symptoms of chronic cardiac and neuromuscular diseases. Primary viral pneumonia was frequently registered in younger adults during the pandemic season, whereas in the post-pandemic season, there were more cases of bacterial pneumonia.

Conclusions: During the pandemic season, the influenza A H1N1pdm09 virus infection caused a severe disease with rare bacterial complications, especially in adult patients. The common characteristics of the influenza A H1N1pdm09 virus were lost in the post-pandemic season, assuming the shape and characteristics of the seasonal influenza A virus.

Author Biography

Jurica Arapovic, University Hospital Mostar, Mostar, Bosnia and Herzegovina

Assistant Professor at the Department of Cellular Biology and Genetics

ID specialist at the Clinic for Infectious Diseases, University Hospital Mostar

Published
2016-02-28
How to Cite
1.
Grgic S, Skocibusic S, Celjuska-Tosev E, Nikolic J, Arapovic J, Kuzman I (2016) Different features of influenza A H1N1pdm09 virus infection among adults in 2009/10 and 2010/11. J Infect Dev Ctries 10:155-162. doi: 10.3855/jidc.6040
Section
Original Articles