Seroprevalence rates of transfusion-transmitted infections among blood donors in Jordan

  • Lina Souan King Hussein Cancer Center, Al-Jubeiha, Amman, Jordan
  • Faten Tout King Hussein Cancer Center, Al-Jubeiha, Amman, Jordan
  • Mahmoud Siag King Hussein Cancer Center, Al-Jubeiha, Amman, Jordan
  • Maher A. Sughayer King Hussein Cancer Center, Al-Jubeiha, Amman, Jordan
Keywords: donors, transfusion-transmitted disease, anti-HBcore total antibody

Abstract

Introduction: Statistics on the prevalence of donor screening for hepatitis B surface antigen (HBsAg) and anti-hepatitis C virus (anti-HCV) in Jordan are outdated. There are no studies on the prevalence of anti-HIV I/II, anti-human T-cell lymphotropic virus type I and II (anti-HTLV-I/II), or anti-syphilis. Data are also lacking on the prevalence and significance of using anti-HBc screening in Jordan. This study aimed to evaluate the prevalence of transfusion-transmissible infections (TTI) among donors at King Hussein Cancer Center and compare it with neighboring countries and to evaluate the significance of screening for anti-HB core total (anti-HBc) antibodies.

Methodology: A retrospective analysis covering the period from 2009 to 2013 was conducted on records of healthy donors. The number of donors was 10,101, 12,694, 13,387, 14,256, and 12,495, respectively. Donors were screened for HBsAg, anti-HBc, anti-HIV I/II, anti-HCV, and anti-HTLV-I/II using ELISA technique, while syphilis antibodies were detected using rapid chromatographic immunoassay.

Results: Among 62,933 donors, the prevalence of HBsAg was 0.52%, of anti-HBc was 6.04%, and of anti-HCV was 0.16%. None of the donors were positive for anti-HIV I/II, anti-HTLV I/II, or anti-TP.

Conclusions: This study demonstrates that the seroprevalence for HBsAg, anti-HBc, and anti-HCV in Jordan was low compared to neighboring countries. None of the donors were confirmed positive for anti-HIV I/II, anti-HTLV I/II, or anti-TP during the studied period. This study demonstrates the importance of screening for anti-HBc to improve blood and platelet safety and stresses the need to complement it with an algorithm that qualifies reentry of anti-HBc false-positive donors.

Author Biographies

Lina Souan, King Hussein Cancer Center, Al-Jubeiha, Amman, Jordan

Head Section, Immunology Lab.

Chief Quality Officer & Deputy Director of KHCCBIO Cancer Biobank

 

Maher A. Sughayer, King Hussein Cancer Center, Al-Jubeiha, Amman, Jordan

Maher A. Sughayer MD, FCAP

Full Member and Chairman,

Published
2016-04-28
How to Cite
1.
Souan L, Tout F, Siag M, Sughayer MA (2016) Seroprevalence rates of transfusion-transmitted infections among blood donors in Jordan. J Infect Dev Ctries 10:377-383. doi: 10.3855/jidc.8160
Section
Original Articles