Carriage prevalence of Salmonella enterica serotype Typhi in gallbladders of adult autopsy cases from Mozambique

  • Lucilia Lovane Maputo Central Hospital, Maputo, Mozambique
  • Miguel J Martinez Universitat de Barcelona, Barcelona, Spain
  • Sergio Massora Centro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique
  • Inacio Mandomando Centro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique
  • Esperança Ussene Maputo Central Hospital, Maputo, Mozambique
  • Dercio Jordao Maputo Central Hospital, Maputo, Mozambique
  • Paola Castillo Universitat de Barcelona, Barcelona, Spain
  • Mamudo R Ismail Maputo Central Hospital, Maputo, Mozambique
  • Cesaltina Lorenzoni Maputo Central Hospital, Maputo, Mozambique
  • Carla Carrilho Maputo Central Hospital, Maputo, Mozambique
  • Quique Bassat Universitat de Barcelona, Barcelona, Spain
  • Clara Menendez Universitat de Barcelona, Barcelona, Spain
  • Jaume Ordi Universitat de Barcelona, Barcelona, Spain
  • Jordi Vila Universitat de Barcelona, Barcelona, Spain
  • Sara Maria Soto Universitat de Barcelona, Barcelona, Spain
Keywords: S. Typhi, carriers, corpses

Abstract

Introduction: Typhoid fever is an important public health problem in many low-income countries where asymptomatic carriers play an important role in its dissemination. The bacterium causing typhoid fever can live in the gallstones of asymptomatic persons after the infection. These carriers are reservoirs of S. Typhi, are highly contagious, and spread the disease through the secretion of bacteria in feces and urine. The aim of this study was to determine the carrier rate in an area of Mozambique.

Methodology: The presence of S. Typhi was analyzed in gallbladder samples obtained from 99 adult corpses (in-hospital deaths) from Mozambique by gold-standard culture and polymerase chain reaction (PCR).

Results: Only one sample was positive with the culture. However, nine additional samples were positive by PCR and confirmed by DNA sequencing. Thus, the prevalence of S. Typhi was 10.1% (10/99).

Conclusions: We report a high prevalence of S. Typhi in gallbladders among adult autopsy cases from Mozambique.

Published
2016-04-28
How to Cite
1.
Lovane L, Martinez MJ, Massora S, Mandomando I, Ussene E, Jordao D, Castillo P, Ismail MR, Lorenzoni C, Carrilho C, Bassat Q, Menendez C, Ordi J, Vila J, Soto SM (2016) Carriage prevalence of Salmonella enterica serotype Typhi in gallbladders of adult autopsy cases from Mozambique. J Infect Dev Ctries 10:410-412. doi: 10.3855/jidc.7306
Section
Brief Original Articles