A rare fatal case of a novel bunyavirus-associated hemophagocytic lymphohistiocytosis

  • Ling Lin Taizhou Hospital of Wenzhou Medical University, Linhai, China
  • You-Zu Xu Taizhou Hospital of Wenzhou Medical University, Linhai, China
  • Xiao-Mai Wu Taizhou Hospital of Wenzhou Medical University, Linhai, China
  • Hong-Fei Ge Taizhou Hospital of Wenzhou Medical University, Linhai, China
  • Jia-Xi Feng Taizhou Hospital of Wenzhou Medical University, Linhai, China
  • Mei-Fang Chen Taizhou Hospital of Wenzhou Medical University, Linhai, China
  • Dong-Qing Lv Taizhou Hospital of Wenzhou Medical University, Linhai, China
  • Bo-Li Li Taizhou Hospital of Wenzhou Medical University, Linhai, China
  • Jian Lin Taizhou Hospital of Wenzhou Medical University, Linhai, China
Keywords: novel bunyavirus, severe fever, thrombocytopenia syndrome, hemophagocytic lymphohistiocytosis, HLH

Abstract

Herein we describe a rare fatal case of a novel bunyavirus-associated hemophagocytic lymphohistiocytosis (HLH) in a 62-year-old female patient. The novel bunyavirus infects patients with or without HLH who have similar clinical features such as fever, thrombocytopenia, and leukocytopenia. Therefore, the diagnosis of HLH can be easily missed. When HLH occurs, the disease worsens and the fatality rate rises. Our finding highlights the importance of bone marrow biopsy performed as soon as possible for patients suspected of having a novel bunyavirus infection and showing marked cytopenia in three cell lines.

Published
2016-05-31
How to Cite
1.
Lin L, Xu Y-Z, Wu X-M, Ge H-F, Feng J-X, Chen M-F, Lv D-Q, Li B-L, Lin J (2016) A rare fatal case of a novel bunyavirus-associated hemophagocytic lymphohistiocytosis. J Infect Dev Ctries 10:533-536. doi: 10.3855/jidc.7268
Section
Case Reports