First molecular evidence of intrauterine and surgical-site infections caused by Streptococcus dysgalactiae subsp. equisimilis

  • Binghuai Lu Civil Aviation General Hospital, Beijing, China
  • Baowei Diao Chinese Centre for Disease Control and Prevention. Beijing, China
  • Yujie Fang Chinese Centre for Disease Control and Prevention. Beijing, China
  • Yanli Shi Civil Aviation General Hospital, Beijing, China
  • Fengxia Zhu Civil Aviation General Hospital, Beijing, China
  • Dong Li Civil Aviation General Hospital, Beijing, China
  • Shuchen Zhang Civil Aviation General Hospital, Beijing, China
  • Yanchao Cui Civil Aviation General Hospital, Beijing, China
  • Duochun Wang Chinese Centre for Disease Control and Prevention. Beijing, China
Keywords: S. dysgalactiae subsp. equisimilis, intrauterine infection, surgical-site infection, molecular evidence

Abstract

S. dysgalactiae subsp. equisimilis (SDSE) is infrequently associated with maternal infections during delivery in pregnant women. A rare case is presented of a woman with intrauterine infection and surgical-site infection due to SDSE after cesarean section, which had colonized her genital tract and, via the ascending pathway, reached her intact fetal membrane. All isolates were identified as Streptococcus Lancefield group G, and their emm genes that coded M protein belonged to stG6.1. The isolates tested negative for a series of streptococcal superantigen virulence genes but positive for nonsuperantigenic virulence genes. In particular, molecular typing using pulsed-field gel electrophoresis analysis disclosed that the three isolates from the different infection sites had identical profiles. Furthermore, multilocus sequence typing indicated that the three isolates belonged to a new sequence typing. Our results indicated that SDSE is potentially pathogenic for pregnant women and newborns if colonized.

Author Biography

Duochun Wang, Chinese Centre for Disease Control and Prevention. Beijing, China
Professor
Published
2016-06-30
How to Cite
1.
Lu B, Diao B, Fang Y, Shi Y, Zhu F, Li D, Zhang S, Cui Y, Wang D (2016) First molecular evidence of intrauterine and surgical-site infections caused by Streptococcus dysgalactiae subsp. equisimilis. J Infect Dev Ctries 10:673-677. doi: 10.3855/jidc.7914
Section
Case Reports