Osteoarticular and soft-tissue melioidosis in Malaysia: clinical characteristics and molecular typing of the causative agent

  • AbdelRahman Mohammad Zueter School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia
  • Mahmoud Abumarzouq School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia
  • Mohd Imran Yusof School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia
  • Wan Faisham Wan Ismail School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia
  • Azian Harun School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia
Keywords: bone, joint, soft tissue, B. pseudomallei, MLST

Abstract

Introduction: Melioidosis involving bone, joints, and soft tissue is rare and reported usually following dissemination of disease from infection elsewhere in the body; to a lesser degree, it can also be reported as the primary manifestation of melioidosis.

Methodology: The orthopedic registry at Hospital University Sains Malaysia from 2008 until 2014 was retrospectively reviewed and was followed by molecular typing of Burkholderia pseudomallei.

Results: Out of 20 cases identified, 19 patients were confirmed to have osteoarticular and/or soft-tissue melioidosis. The majority of the patients were males (84%), and 16 patients had underlying diabetes mellitus with no significant estimated risk with the disease outcomes. Bacterial genotype was not associated with the disease as a risk. Death was a significant outcome in patients with bacteremic infections (p = 0.044).

Conclusion: Patients with lung or skin melioidosis require careful treatment follow-up to minimize the chance for secondary osteoarticular infection. Human risk factors remain the leading predisposing factors for melioidosis. Early laboratory and clinical diagnosis and acute-phase treatment can decrease morbidity and mortality.

Author Biographies

AbdelRahman Mohammad Zueter, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia

Department of Medical Microbiology and Parasitology

MLS (PhD)

Mahmoud Abumarzouq, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia

Department of Orthopedic

MD, orthopedic

Mohd Imran Yusof, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia

Department of Orthopedic

MD, orthopedic

Wan Faisham Wan Ismail, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia

Department of Orthopedic

MD, Orthopedoc

Azian Harun, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia

Department of Medical Microbiology and Parasitology

MD, MPath, PhD

Published
2017-01-30
How to Cite
1.
Zueter AM, Abumarzouq M, Yusof MI, Wan Ismail WF, Harun A (2017) Osteoarticular and soft-tissue melioidosis in Malaysia: clinical characteristics and molecular typing of the causative agent. J Infect Dev Ctries 11:28-33. doi: 10.3855/jidc.7612
Section
Original Articles