Geohelminths: public health significance

  • Suvash Chandra Ojha Mahidol University, Bangkok, Thailand
  • Chayannan Jaide Mahidol University, Bangkok, Thailand
  • Natini Jinawath Mahidol University, Bangkok, Thailand
  • Porpon Rotjanapan Mahidol University, Bangkok, Thailand
  • Pankaj Baral Mahidol University, Bangkok, Thailand
Keywords: geohelminths, immune response, pathogenesis, prevalence, treatment, nematodes

Abstract

The worldwide prevalence of geohelminths and their unique place in evolutionary biology have attracted research focus. These major soil-transmitted intestinal nematodes that cause human diseases are the nematode roundworm (Ascaris lumbricoides), the whipworm (Trichuris trichiura) and the two hookworms (Ancylostoma duodenale and Necator americanus), often collectively referred as geohelminths. Studies of geohelminthiasis in poorly nourished children in developing regions report that geohelminths contribute to stunted growth and cognitive impairment. Insights into immunology have shed light on the modulatory role of the parasite on the host immune system and have defined the role of T cells in controlling geohelminthic infection. Recent molecular biological techniques have created an opportunity to analyse the interaction between parasites and their hosts at the molecular level. This paper is a review of the recent literature that examined the prevalence of geohelminthiasis in developing countries, the association between geohelminths in relation to public health, parasitological/diagnostic features, and therapeutic and preventive aspects of these major soil-transmitted helminth (STH) pathogens in humans.

Author Biographies

Suvash Chandra Ojha, Mahidol University, Bangkok, Thailand

PhD (scholar) in Molecular Medicine,

Faculty of Science, Mahidol University

Chayannan Jaide, Mahidol University, Bangkok, Thailand

Lecturer in Faculty of Medicine Ramathibodi Hospital,

Mahidol University

Natini Jinawath, Mahidol University, Bangkok, Thailand

Lecturer in Faculty of Medicine Ramathibodi Hospital,

Mahidol University

Porpon Rotjanapan, Mahidol University, Bangkok, Thailand

Lecturer in Faculty of Medicine Ramathibodi Hospital,

Mahidol University

Pankaj Baral, Mahidol University, Bangkok, Thailand

PhD in Microbiology

Department of Microbiology, Mahidol University, Thailand

Published
2014-01-15
How to Cite
1.
Ojha S, Jaide C, Jinawath N, Rotjanapan P, Baral P (2014) Geohelminths: public health significance. J Infect Dev Ctries 8:005-016. doi: https://doi.org/10.3855/jidc.3183
Section
Reviews