Hematological profile in natural progression of giardiasis: kinetics of experimental infection in gerbils
Introduction: The clinical manifestations of giardiasis and its impact are harmful to children, and may cause deficits in their physical and cognitive development. The pathogenic mechanisms are usually unknown and the available reports can be controversial.
Methodology: The present study aimed to know, for the first time, the evolution of the hematological profile of the gerbils, experimentally infected with Giardia lamblia, up to the infection’s resolution. Hematological variables have been tested.
Results: White blood cells have not presented meaningful alterations during the course of the infection. A significant reduction in the number of red blood cells (p = 0.021), in the concentration of hemoglobin (p = 0.029) and in the value of the hematocrit (p = 0.016) has been observed, starting from the second week of infection, ratifying an anemia related to giardiasis. Reduction in the level of serum iron starting from the third week of infection, despite not being significant, could suggest the participation of iron in the anemia. However, the weight of the animals was kept and the hematimetric parameters started to return to the basic values after the parasitological cure without iron reposition.
Conclusions: The outcomes found suggest the idea that not only malabsorption but also other mechanisms such as chronic inflammation may be implicated in iron deficiency anemia in giardiasis and may explain how asymptomatic patients may have anemia without malabsorption. In this context, considering the highlighting character of the anemia in our study, we believe that anemia should be investigated in children with giardiasis. And in the cases of anemia without a definite etiology, giardiasis should also be investigated.
Copyright (c) 2018 Maria Gomes, Frederico Gil, Luciana Ventura, Joice Fonseca, Helton Saniago, Haendel Busatti, Joseph Santos
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).