Levels of different cytokines in women and men with asymptomatic genital infection caused by Chlamydia

Alessandra Bua; Sara Cannas; Stefania Zanetti; Paola Molicotti

doi:10.3855/jidc.9810

Levels of different cytokines in women and men with asymptomatic genital infection caused by Chlamydia

Authors

Alessandra Bua Department of Biomedical Sciences, Section of Experimental and Clinical Microbiology, University of Sassari, Sassari, Italy
Sara Cannas Department of Biomedical Sciences, Section of Experimental and Clinical Microbiology, University of Sassari, Sassari, Italy
Stefania Zanetti Department of Biomedical Sciences, Section of Experimental and Clinical Microbiology, University of Sassari, Sassari, Italy
Paola Molicotti Department of Biomedical Sciences, Section of Experimental and Clinical Microbiology, University of Sassari, Sassari, Italy

DOI:

https://doi.org/10.3855/jidc.9810

Keywords:

infection, Chlamydia, interleukin-10, interleukin-17, cytokine

Abstract

Introduction: Immune response to genital Chlamydia trachomatis infection is involved in both immunity and pathology. The cytokine profile during infection has been implicated in the disease outcome, either resolution or severe sequelae.

Methodology: In total, 3900 patients were analyzed for presence of genital infections caused by Chlamydia using molecular assays. Interleukins (IL) IL-10, IL-17, IL-6, IL-2 and chemokine IP-10 were estimated by ELISA in urine, cervical swabs and semen samples. Statistical analysis was performed using the T student test.

Results: A total of 47 out of 3900 samples (1.2%) were found to be positive for Chlamydia trachomatis based on the Real Time (RT) PCR results. Statistical analysis revealed that the differences between Chlamydia trachomatis positive and negative samples regarding levels of cytokines were not signiﬁcant.

Conclusions: Our results demonstrated that no signiﬁcant difference in cytokine concentrations exists in Chlamydia trachomatis infected patients when compared to healthy controls. In further study, we aim to test on a greater number of positive samples a greater number of cytokines involved in the immune response to Chlamydia trachomatis infections.

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Published

2019-09-30

How to Cite

Bua A, Cannas S, Zanetti S, Molicotti P (2019) Levels of different cytokines in women and men with asymptomatic genital infection caused by Chlamydia. J Infect Dev Ctries 13:847–850. doi: 10.3855/jidc.9810

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Issue

Vol. 13 No. 09: September 2019

Section

Brief Original Articles

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