The role of plasma presepsin levels in determining the incidence of septic shock and mortality in patients with sepsis

  • Ugur Kahveci Department of Emergency Medicine, Eskisehir City Hospital, Eskisehir, Turkey
  • Seda Ozkan Department of Emergency Medicine, Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Istanbul, Turkey
  • Adem Melekoglu Department of Emergency Medicine, Sisli Etfal Training and Research Hospital, Istanbul, Turkey
  • Eren Usul Department of Emergency Medicine, Sincan State Hospital, Ankara, Turkey
  • Gulfer Ozturk Department of Clinical Biochemistry, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey
  • Esra Cetin Department of Clinical Biochemistry, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey
  • Kerim Abatay Department of Emergency Medicine, Muş State Hospital, Muş, Turkey
  • Ali Sahin Department of Emergency Medicine, Etimesgut Şehit Sait Ertürk State Hospital, Ankara, Turkey
Keywords: Sepsis, septic shock, presepsin, prognosis, mortality

Abstract

Introduction: The present study aimed to investigate the role of plasma presepsin in the early detection of septic shock and in determining the prognosis and mortality of patients with sepsis.

Methodology: The study was conducted in the emergency department between 1 January 2017 and 1 July 2017. A total of 106 patients 18 years of age or older who were diagnosed with sepsis according to the quick sequential organ failure assessment (qSOFA) criteria were included in this prospective study. The patients’ symptoms, vital signs, additional diseases, demographic attributes, laboratory results, Mortality in Emergency Department Sepsis (MEDS) scores, imaging findings and treatments were recorded. Moreover, the patients’ blood samples were collected to measure plasma presepsin, procalcitonin and CRP levels.

Results: In total, 55.7% of the patients were female. The median age of the patients was 78 (24–103) years, and their 30-day mortality rate was 67%. The presepsin level was significantly higher in the sepsis group than in the healthy control group (p < 0.001). The presepsin levels did not differ significantly between the sepsis and septic shock groups (p = 0.12). Similarly, the procalcitonin levels did not differ significantly between the sepsis and septic shock groups (p > 0.05). There was no significant difference in the presepsin, procalcitonin and CRP levels between survivor and non-survivor patients (p = 0.74).

Conclusions: The plasma presepsin level was found to be ineffective in determining the incidence of septic shock and mortality in patients with sepsis in the emergency department.

Published
2021-01-31
How to Cite
1.
Kahveci U, Ozkan S, Melekoglu A, Usul E, Ozturk G, Cetin E, Abatay K, Sahin A (2021) The role of plasma presepsin levels in determining the incidence of septic shock and mortality in patients with sepsis. J Infect Dev Ctries 15:123-130. doi: 10.3855/jidc.12963
Section
Original Articles