Clinical and mycological characteristics of keratitis caused by Colletotrichum gloeosporioides: A case report and review of literature

  • Alireza Izadi Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  • Mohammad Soleimani Department of Ocular Trauma and Emergency, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran
  • Roshanak Daie Ghazvini Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  • Seyed Jamal Hashemi Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  • Mohssen Gramishoar Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  • Kazem Ahmadikia Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  • Mehdi Aminizadeh Department of Ocular Trauma and Emergency, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran
  • Mohammad Ghahri Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran
  • Zohre Abedinifar Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran
  • Aleksandra Barac Clinic for Infectious and Tropical Diseases, Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Belgrade, Serbia
  • Sadegh Khodavaisy Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
Keywords: Colletotrichum gloeosporioides, keratitis, molecular identification

Abstract

Introduction: Colletotrichum species are well-known plant pathogens, which have been increasingly reported as the cause of keratitis or subcutaneous lesions in humans. In this study we reported a rare case of fungal keratitis from Iran and reviewed the literature.

Case Presentation: A 69-year-old man whose right eye was injured by herbal material was examined by slit-lamp biomicroscopy and mycology investigation of corneal scrapings was done. The grown filamentous fungal was identified as Colletotrichum gloeosporioides based on morphological characteristics and DNA sequence of the internal transcribed spacer region. The isolated strain was sensitive to amphotericin B, caspofungin, anidolafungin, micafungin, voriconazole, and relatively resistant to fluconazole, and itraconazole. Patient was successfully treated with voriconazole.

Conclusions: This report highlights that the early and accurate identification and therapy can helpful to management keratitis caused by C. gloeosporioides.

Published
2021-03-07
How to Cite
1.
Izadi A, Soleimani M, Daie Ghazvini R, Hashemi SJ, Gramishoar M, Ahmadikia K, Aminizadeh M, Ghahri M, Abedinifar Z, Barac A, Khodavaisy S (2021) Clinical and mycological characteristics of keratitis caused by Colletotrichum gloeosporioides: A case report and review of literature. J Infect Dev Ctries 15:301-305. doi: 10.3855/jidc.14492
Section
Case Reports