Treatment success using novel and adapted treatment regimens in registered DR-TB children in Dushanbe, Tajikistan, 2013-2019

  • Bobojon Pirmahmadzoda Dushanbe City Center of Protection of the Population from Tuberculosis, Dushanbe, Tajikistan
  • Katrina Hann Sustainable Health Systems, Freetown, Sierra Leone
  • Kristina Akopyan TB Research and Prevention Center, Yerevan, Armenia
  • Ruzanna Grigoryan TB Research and Prevention Center, Yerevan, Armenia
  • Evgenia Geliukh International Charitable Foundation “Alliance for Public Health”
  • Sharifzoda Hushvaht Department of Health Care of Dushanbe, Tajikistan
  • Odinaeva Surayo Dushanbe City Center of Protection of the Population from Tuberculosis, Dushanbe, Tajikistan
  • Zulfiya Tilloeva Dushanbe City Center of Protection of the Population from Tuberculosis, Dushanbe, Tajikistan
Keywords: Bedaquiline, Delamanid individual regimen, short regimen, treatment outcome, SORT-IT

Abstract

Introduction: Approximately 3% of all pediatric TB cases develop MDR-TB, with only 3–4% of such children receiving MDR-TB treatment. In Tajikistan, children as a proportion of all DR-TB in the country increased from 4.3 to 7.5% during 2013-2018. Despite limited evidence on the use of new anti-TB drugs in children, WHO has updated its guidelines for DR-TB treatment for children, and Tajikistan did so in 2013 and 2017. Novel and adapted regimens included individual regimens for RR/MDR, XDR (with and without Bedaquiline and Delamanid) and short treatment regimens with and without injectables. It is important to document the outcomes of the treatment regimens. Therefore, the aim of this study was to describe characteristics of children receiving different treatment regimens for DR-TB, the culture conversion and treatment outcomes.

Methodology: Cohort study of children enrolled in DR-TB treatment by the National Tuberculosis Program in Dushanbe, Tajikistan, January 2013 to July 2019.

Results: The study included 60 DR-TB children. The male to female ratio was 1:2 and mean age 13.6 years. Median time to culture conversion was 66 days [IQR:31-103; Range:2-232]. In children with treatment outcomes (N = 58), 93% had favorable outcomes. There were four children (7%) with unfavorable treatment outcomes, all of whom were female 15-17 years, on standard (RR/MDR) treatment during 2013-2015. Favorable outcomes by DR-TB type were 91%, 90%, and 100% in RR/MDR, PreXDR, and XDR-TB patients, respectively.

Conclusions: All children enrolled after the introduction of modified guidelines for novel and adapted regimens for DR-TB showed positive TB treatment outcomes.

Published
2021-09-29
How to Cite
1.
Pirmahmadzoda B, Hann K, Akopyan K, Grigoryan R, Geliukh E, Hushvaht S, Surayo O, Tilloeva Z (2021) Treatment success using novel and adapted treatment regimens in registered DR-TB children in Dushanbe, Tajikistan, 2013-2019. J Infect Dev Ctries 15:7S-16S. doi: 10.3855/jidc.14798
Section
EECA Regional SORT IT

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