Prevalence of precancerous cervical lesions and high-risk human papillomavirus types in Yaounde, Cameroon

  • Richard Tagne Simo Department of Biomedical Sciences, Faculty of Science, University of Ngaoundere, Cameroon
  • Arsène G Djoko Nono Department of Biomedical Sciences, Faculty of Science, University of Ngaoundere, Cameroon
  • Hervet Paulin Fogang Dongmo Department of Physiological Sciences and Biochemistry, FMBS, University of Ngaoundere, Garoua, Cameroon
  • Paul F Seke Etet Department of Physiological Sciences and Biochemistry, FMBS, University of Ngaoundere, Garoua, Cameroon
  • Bertrand Kiafon Fonyuy Anato-Cytopathology Laboratory, Centre Hospitalier Dominicain Saint Martin de Porres, Yaounde, Cameroun
  • Armel H Nwabo Kamdje Department of Physiological Sciences and Biochemistry, FMBS, University of Ngaoundere, Garoua, Cameroon
  • Nicolas Njintang Yanou Department of Biological Sciences, Faculty of Sciences, University of Ngaoundere, Ngaoundere, Cameroon
  • Phélix Bruno Telefo Department of Biochemistry, Faculty of Science, University of Dschang, Cameroon
Keywords: Cervical cancer, HPV, genotyping, co-infection

Abstract

Introduction: Various Human papillomavirus (HPV) types cause cervical cancer, and represent the primary cause of cancer death in Africa and the second cause of most common cancers in Cameroon. Herein, we determined the prevalence of high-risk HPV types in women and associated cervical cytologic abnormalities in Yaounde, Cameroon.

Methodology: A cross-sectional study targeting HPV-positive women aged 20 and over was conducted between March and June 2020 at the Saint Martin de Porres’ Health Centre in Yaounde. HPV tests were performed by PCR for detection of HPVs 16, 18, 33, and 45. The test was performed on 616 women using exfoliated cell specimens; then, we processed on cytological diagnosis with Pap smears on HPV positive specimens.

Results: The HPV types tested were detected in 137 participants, of which 38.7% with multiple HPV infections, and the remaining part with single HPV infections of type HPV 16 (28.5%), HPV 18 (17.5%), HPV 33 (10.2%), and HPV 45 (5.1%). Cervical cytologic abnormalities were found in 69.34% of participants including: LSIL (49.63%), HSIL (15.32%), ASC-US (3.66%) and AGC (0.73%). Co-infections with HPV 16 and HPV 18 were significantly associated with HSIL (p = 0.001) lesions, while HPV 45 was more common in participants with normal cytology (p = 0.001). Cervical lesion occurrence was significantly associated with the number of sexual partners (p = 0.02) and history of oral contraceptive pill use (p = 0.001).

Conclusions: Our results suggest that HPV 16 and 18 are predominant in Yaounde, and are associated with more severe precancerous lesions.

Published
2021-09-30
How to Cite
1.
Tagne SimoR, Djoko NonoAG, Fogang DongmoHP, Seke EtetPF, Fonyuy BK, Kamdje AHN, Yanou NN, Telefo PB (2021) Prevalence of precancerous cervical lesions and high-risk human papillomavirus types in Yaounde, Cameroon. J Infect Dev Ctries 15:1339-1345. doi: 10.3855/jidc.15218
Section
Original Articles