Prevalence and risk factor analysis for HIV/HTLV 1/2 coinfection in Paraíba state, Brazil

  • Marcela Santos de Souza Virology Sector, Keizo Asami Immunopathology Laboratory, Federal University of Pernambuco, Recife, Pernambuco, Brazil
  • Juliana Prado Gonçales Virology Sector, Keizo Asami Immunopathology Laboratory, Federal University of Pernambuco, Recife, Pernambuco, Brazil
  • Viviane Martha Santos deMorais Virology Sector, Keizo Asami Immunopathology Laboratory, Federal University of Pernambuco, Recife, Pernambuco, Brazil
  • José Valter Joaquim Silva Júnior Virology Sector, Keizo Asami Immunopathology Laboratory, Federal University of Pernambuco, Recife, Pernambuco, Brazil
  • Thaísa Regina Rocha Lopes Virology Sector, Keizo Asami Immunopathology Laboratory, Federal University of Pernambuco, Recife, Pernambuco, Brazil
  • Joanne Elizabeth Ferraz da Costa Virology Sector, Keizo Asami Immunopathology Laboratory, Federal University of Pernambuco, Recife, Pernambuco, Brazil
  • Maria Rosângela Cunha Duarte Côelho Virology Sector, Keizo Asami Immunopathology Laboratory, Federal University of Pernambuco, Recife, Pernambuco, Brazil
Keywords: HIV/AIDS, HTLV 1/2, Epidemiology, Brazil

Abstract

Introduction: Human T-lymphotropic virus (HTLV) 1 and 2 infections can lead to neurological diseases, mainly in HIV/HTLV 1 coinfected. Furthermore, HTLV 1 infection in HIV/AIDS patients has also been associated with AIDS progression. Despite this, HTLV 1/2 infections are not of mandatory notification in Brazil. Here, we describe the prevalence of HTLV 1/2 in HIV/AIDS patients from Paraíba state, Brazil, as well as the sociodemographic characteristics of the coinfected individuals.

Methodology: Information about HIV viral load and TCD4 lymphocyte count were obtained from patients’ records. Data on the patients’ sociodemographic characteristics were obtained by interview conducted after signing the informed consent form. The serological diagnosis for HTLV 1/2 was performed by Enzyme-Linked Immunosorbent Assay (ELISA) and Western Blot (WB).

Results: A total of 401 HIV/AIDS patients participated in the study, of whom about 1.5% (6/401) were positive for antibodies against HTLV, specifically for HTLV 1, evaluated by both ELISA and WB. No risk factors were found associated with HIV/HTLV 1/2 coinfection.

Conclusions: We report a 1.5% prevalence of HTLV 1 infection in HIV/AIDS patients from Paraíba state. Although we have not identified risk factors associated with HTLV 1, we describe the most observed sociodemographic characteristics in HIV/HTLV 1 coinfection.

Published
2021-10-31
How to Cite
1.
Santos de Souza M, Prado Gonçales J, Santos deMorais VM, Silva Júnior JVJ, Lopes TRR, Costa JEF da, Côelho MRCD (2021) Prevalence and risk factor analysis for HIV/HTLV 1/2 coinfection in Paraíba state, Brazil. J Infect Dev Ctries 15:1551-1554. doi: 10.3855/jidc.14602
Section
Brief Original Articles