Effectiveness of palivizumab immunoprophylaxis in infants with respiratory syncytial virus disease in Colombia

  • Juan Gabriel Piñeros Santa Fe Foundation University Hospital, Bogota, DC, Colombia
  • Jose De la Hoz-Valle Santa Fe Foundation University Hospital, Bogota, DC, Colombia
  • Clara Galvis Central Military Hospital, Bogota, DC, Colombia
  • Astrid Celis Simón Bolívar Hospital, Bogota, Colombia
  • Oscar Ovalle Maternal and Child Clinic, SaludCoop. Bogota Colombia
  • Carmen Cecilia Sandoval Coomeva Kangaroo Plan, Bucaramanga, Colombia
  • Jaime Orrego Valle de Lili Clinic Foundation, Cali, Colombia
  • Saby Vides Coomeva Kangaroo Plan, Bucaramanga, Colombia
  • Iader Rojas Caribe Clinic, Cartagena, Colombia
  • Hernando Bustamante Bocagrande Hospital, Cartagena, Colombia
  • Carlos Gallón North General Clinic, Barranquilla, Colombia
  • Jaime Alberto Mesa Comfamiliar Risaralda Clinic, Technological University of Pereira, Colombia
Keywords: Palivizumab, Prophylaxis, Respiratory syncytial virus, Lower respiratory tract infectio

Abstract

Introduction: Respiratory syncytial virus (RSV) is one of the most important childhood infections. Objective: To evaluate the effectiveness and safety of palivizumab immunoprophylaxis in preterm infants at a high risk of severe respiratory syncytial virus infection during the RSV season in Colombia.

Methodology: A prospective observational non-comparative multicenter study in six Colombian cities. At the beginning of the RSV infection season, palivizumab prophylaxis, up to five doses, was administered to infants born at ≤32 weeks of gestation, infants younger than six months, infants under one year of age with bronchopulmonary dysplasia (BPD), infants one year or less of age with hemodynamically significant acyanotic and non-acyanotic congenital heart disease (CHD), and with follow-up during the immunoprophylaxis until one month after the last dose.

Results: The study enrolled 600 patients, 91.8% of which were born at ≤ 32 weeks of gestation. BPD was observed in 54.9% of infants. 49% were born at < 32 weeks gestation and presented BPD. 6.9% had hemodynamically significant acyanotic and non-acyanotic CHD 53.3% received three or more doses of palivizumab. The mean interval between doses was 39.6 days. 1.8% of patients were hospitalized due to a confirmed RSV infection. Overall mortality was 1.2%, whereas the mortality by RSV in infants undergoing prophylaxis was 0.2%.

Conclusions: Palivizumab was a clinically effective, well-tolerated treatment in the Colombian population. The safety profile of palivizumab reflects the findings from previous studies in developed countries.

Published
2021-11-30
How to Cite
1.
Piñeros JG, De la Hoz-ValleJ, Galvis C, Celis A, Ovalle O, Sandoval CC, Orrego J, Vides S, Rojas I, Bustamante H, Gallón C, Mesa JA (2021) Effectiveness of palivizumab immunoprophylaxis in infants with respiratory syncytial virus disease in Colombia. J Infect Dev Ctries 15:1708-1713. doi: 10.3855/jidc.12561
Section
Original Articles