Assessment of pathomorphological characteristics of the oral mucosa in patients with HBV, HCV and HIV

  • Vahe Azatyan Department of Therapeutic Stomatology, Yerevan State Medical University (YSMU), Yerevan, Armenia
  • Lazar Yessayan Department of Therapeutic Stomatology, Yerevan State Medical University (YSMU), Yerevan, Armenia
  • Anna Khachatryan Department of Pathological Anatomy, Yerevan State Medical University (YSMU), Yerevan, Armenia
  • Anush Perikhanyan Department of Medical Affairs, FMD Contract Research Organization, Yerevan, Armenia
  • Alvard Hovhannisyan Department of Infectious Diseases, Yerevan State Medical University (YSMU), Yerevan, Armenia
  • Melanya Shmavonyan Department of Infectious Diseases, Yerevan State Medical University (YSMU), Yerevan, Armenia
  • Hasmik Ghazinyan Department of Hepatology, Nork Clinical Infectious Hospital (CJSC), Yerevan, Armenia
  • Robert Gish Department of Medicine, Stanford University Hospital, Stanford, California, United States
  • Gayane Melik-Andreasyan National Center of Disease Control and Prevention, RA Ministry of Health, Yerevan, Armenia
  • Kristina Porksheyan Department of Diagnostic Radiology, Yerevan State Medical University (YSMU), Yerevan, Armenia
Keywords: Histology, oral mucosa, HBV, HCV, HIV

Abstract

Introduction: Oral clinical manifestations in HBV HCV and HIV patients indicate a deterioration in general health status. The aim of the study was to assess pathomorphologic features of oral mucosa observed in patients with these diseases.

Methodology: The study was conducted in N1 Dental Clinic of YSMU after M. Heratsi. The total number of patients taking part in the research was 120, including HBV (n = 40), HCV (n = 40) and HIV (n = 40). After biopsy and subsequent histological examination of the oral mucosa, statistical analysis was carried out using Excel 2013 and R software.

Results: Pathomorphological examination revealed inflammatory infiltrations in all samples collected from HBV, HCV and HIV patients. These changes included microcirculatory disorders in 98.3% of samples: fibrinous-like deposits lining the surface of erosions and ulcers on the oral mucosa (1.67%), fibrosis of the mucous membrane (70%), dystrophy of squamous epithelium (93.3%) and bone sequestration (3.3%). Comparative analysis of pathomorphological characteristics revealed distinct content of infiltrates: lymphoplasmacytic infiltration in patients with HBV and HCV, while HIV patients showed neutrophils infiltration and lack of plasmocytes.

Conclusions: There are common abnormal morphological changes in the oral mucosa typical of all patients with HBV, HCV and HIV, as well as liver diseases specific to each of them. Inflammation in the patients with HIV indicated impairment of the humoral immune system. Understanding the distinct characteristic of inflammation in the oral cavity could be useful for early differential diagnosis and management of patients with HIV, HBV and HCV.

Published
2021-11-30
How to Cite
1.
Azatyan V, Yessayan L, Khachatryan A, Perikhanyan A, Hovhannisyan A, Shmavonyan M, Ghazinyan H, Gish R, Melik-Andreasyan G, Porksheyan K (2021) Assessment of pathomorphological characteristics of the oral mucosa in patients with HBV, HCV and HIV. J Infect Dev Ctries 15:1761-1765. doi: 10.3855/jidc.15062
Section
Brief Original Articles

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