High mortality at the beginning of the COVID-19 pandemic in a referral center in the metropolitan area of Mexico City

  • Alberto Ordinola Navarro Department of Infectious Disease, National Institute of Medical Science and Nutrition Salvador Zubiran, Mexico City, Mexico
  • Orestes de Jesús Cobos-Quevedo Department of Internal Medicine, Hospital de Especialidades "Dr. Antonio Fraga Mouret", Centro Médico Nacional La Raza del Instituto Mexicano del Seguro Social, Mexico City, Mexico
  • Javier Cervantes-Bojalil Department of Internal Medicine, Hospital de Especialidades "Dr. Antonio Fraga Mouret", Centro Médico Nacional La Raza del Instituto Mexicano del Seguro Social, Mexico City, Mexico
  • Esperanza Pérez Álvarez Department of Infectious Diseases, National Medical Center November 20 ISSTE, Mexico City, Mexico
  • Andrea González Gil Department of Internal Medicine, Hospital de Especialidades "Dr. Antonio Fraga Mouret", Centro Médico Nacional La Raza del Instituto Mexicano del Seguro Social, Mexico City, Mexico
  • Ana Lilia Peralta-Amaro Department of Internal Medicine, Hospital de Especialidades "Dr. Antonio Fraga Mouret", Centro Médico Nacional La Raza del Instituto Mexicano del Seguro Social, Mexico City, Mexico
  • Ana Laura Carrillo-González Department of Internal Medicine, Hospital de Especialidades "Dr. Antonio Fraga Mouret", Centro Médico Nacional La Raza del Instituto Mexicano del Seguro Social, Mexico City, Mexico
  • Arturo Olvera Acevedo Department of Internal Medicine, Hospital de Especialidades "Dr. Antonio Fraga Mouret", Centro Médico Nacional La Raza del Instituto Mexicano del Seguro Social, Mexico City, Mexico
  • Luis Francisco Pineda-Galindo Department of Internal Medicine, Hospital de Especialidades "Dr. Antonio Fraga Mouret", Centro Médico Nacional La Raza del Instituto Mexicano del Seguro Social, Mexico City, Mexico
  • Fernando Briceño-Moya Department of Internal Medicine, Hospital de Especialidades "Dr. Antonio Fraga Mouret", Centro Médico Nacional La Raza del Instituto Mexicano del Seguro Social, Mexico City, Mexico
  • Olga Lidia Vera-Lastra Department of Internal Medicine, Hospital de Especialidades "Dr. Antonio Fraga Mouret", Centro Médico Nacional La Raza del Instituto Mexicano del Seguro Social, Mexico City, Mexico
  • Bruno Ali Lopez Luis Department of Infectious Diseases, National Medical Center November 20 ISSTE, Mexico City, Mexico
Keywords: COVID-19, epidemiology, Mexico, mortality, pandemic, SARS-CoV-2

Abstract

Introduction: There is limited information about the coronavirus disease 2019 (COVID-19) disease in Latin-American countries. Our objective was to describe the clinical characteristics and outcomes of COVID-19 patients in Mexico.

Methodology: We conducted a retrospective cohort study with 333 consecutive patients who were admitted to Hospital de Especialidades "Dr. Antonio Fraga Mouret" in Mexico City with COVID-19 between April 1, 2020, and June 30, 2020. Demographic, clinical, laboratory data, treatment details and 30-day outcomes were analyzed.

Results: The patients studied included 52% men (172/233) and the median age was 45 years. Up to 75% (250/333) of patients were classified as overweight or obese. There were 185 (56%) inpatients; 85% (158/185) were hospitalized in the general ward, and 15% (27/185) in the Intensive Care Unit (ICU). Laboratory measurements showed significant differences between inpatients and outpatients such as lymphocyte-count (median 0.8 vs 1.2×109/L, p < 0.001), LDH (median 650 vs 294 U/L, p < 0.001), CRP (median 147 vs 5 mg/L, p = 0.007), CK-MB (median, 15 vs 10 U/L, p = 0.008), ferritin (median, 860 vs 392 ng/mL, p = 0.02), and D-dimer (median, 780 vs 600 ng/mL, p = 0.15). These differences were seen between survivor and non-survivor patients as well. The rate of death in mechanically ventilated patients was 94% (67/71). Mortality at 30-day follow-up was 57% (105/185).

Conclusions: We observed that majority of the non-survivors were obese and young. Complications leading to death was observed in majority of the cases.

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Published
2022-08-30
How to Cite
1.
Ordinola NavarroA, Cobos-QuevedoO de J, Cervantes-BojalilJ, Pérez ÁlvarezE, González GilA, Peralta-AmaroAL, Carrillo-GonzálezAL, Olvera AcevedoA, Pineda-GalindoLF, Briceño-MoyaF, Vera-LastraOL, Lopez LuisBA (2022) High mortality at the beginning of the COVID-19 pandemic in a referral center in the metropolitan area of Mexico City. J Infect Dev Ctries 16:1269-1277. doi: 10.3855/jidc.14389
Section
Coronavirus Pandemic