High mortality at the beginning of the COVID-19 pandemic in a referral center in the metropolitan area of Mexico City
Introduction: There is limited information about the coronavirus disease 2019 (COVID-19) disease in Latin-American countries. Our objective was to describe the clinical characteristics and outcomes of COVID-19 patients in Mexico.
Methodology: We conducted a retrospective cohort study with 333 consecutive patients who were admitted to Hospital de Especialidades "Dr. Antonio Fraga Mouret" in Mexico City with COVID-19 between April 1, 2020, and June 30, 2020. Demographic, clinical, laboratory data, treatment details and 30-day outcomes were analyzed.
Results: The patients studied included 52% men (172/233) and the median age was 45 years. Up to 75% (250/333) of patients were classified as overweight or obese. There were 185 (56%) inpatients; 85% (158/185) were hospitalized in the general ward, and 15% (27/185) in the Intensive Care Unit (ICU). Laboratory measurements showed significant differences between inpatients and outpatients such as lymphocyte-count (median 0.8 vs 1.2×109/L, p < 0.001), LDH (median 650 vs 294 U/L, p < 0.001), CRP (median 147 vs 5 mg/L, p = 0.007), CK-MB (median, 15 vs 10 U/L, p = 0.008), ferritin (median, 860 vs 392 ng/mL, p = 0.02), and D-dimer (median, 780 vs 600 ng/mL, p = 0.15). These differences were seen between survivor and non-survivor patients as well. The rate of death in mechanically ventilated patients was 94% (67/71). Mortality at 30-day follow-up was 57% (105/185).
Conclusions: We observed that majority of the non-survivors were obese and young. Complications leading to death was observed in majority of the cases.
Copyright (c) 2022 Alberto Ordinola Navarro, Javier Cervantes Bojalil, Orestes de Jesus Cobos Quevedo, Esperanza Perez Álvarez, Andrea González Gil, Ana Lilia Peralta Amaro, Ana Laura Carrillo González, Arturo Olvera Acevedo, Luis Francisco Pineda Galindo, Fernando Briceño Moya, Olga Lidia Vera Lastra, Bruno Ali Lopez Luis
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