Is there an association between recurrent spontaneous abortion and mycoplasma infection?

  • Jie Yu Department of Obsterics and Gynecology, Haidian Maternal and Child Health Care Hospital, Beijing, China
  • Shanshan Yu Department of Pharmacy, Fifth Medical Center of PLA General Hospital, Beijing, China
  • Liye Zhu Department of Obsterics and Gynecology, Haidian Maternal and Child Health Care Hospital, Beijing, China
  • Xuan Sun Department of Laboratory, Haidian Maternal and Child Health Care Hospital, Beijing, China
  • Boqi Lu Department of Obsterics and Gynecology, Haidian Maternal and Child Health Care Hospital, Beijing, China
  • Jian Li Intensive Care Unit, Tianjin Chest Hospital, Tianjin, China
  • Yuecheng Hu Department of Cardiology, Tianjin Chest Hospital, Tianjin,China
  • Peijun Li Intensive Care Unit, Tianjin Chest Hospital, Tianjin, China
Keywords: Abortion, mycoplasma, ureaplasma

Abstract

Introduction: Recurrent spontaneous abortion (RSA) is an important reproductive health issue with a serious adverse effect on patients and their families worldwide. The present study evaluated the association between mycoplasma infections and RSA in pregnant patients.

Methodology: This case-control study included 107 patients with RSA (study group) and 89 normal pregnant women who had planned abortions (control group) between March 2019 and February 2021. Cervical swabs were assessed for the presence of Mycoplasma hominis and Ureaplasma urealyticum by Microtiter Plate Hybridization assay.

Results: A total of 52 (48.6%) patients from the study group and 13 (14.6%) patients from control group were positive for mycoplasmas. The presence of M. hominis (29.9% vs. 9%; p = 0.024), U. urealyticum (18.7% vs. 5.6%; p = 0.015) and the co-infection of M. hominis/U. urealyticum (14% vs. 1%; p = 0.032) were significantly higher in the study group. Multivariate analysis revealed that pelvic pain (Odds Ratio [OR] = 3.42; 95% CI = 0.40-3.65; p = 0.015), dysuria (OR = 4.12; 95% CI = 1.59-8.23; p = 0.021), and urinary tract infection (OR = 3.97; 95% CI = 1.52-4.17; p = 0.032) were independent predictors of RSA.

Conclusions: The high prevalence of M. hominis/U. urealyticum in this study reveals a significant association with RSA. Pelvic pain and Mycoplasma infections are independent predictors of RSA.

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Published
2022-08-30
How to Cite
1.
Yu J, Yu S, Zhu L, Sun X, Lu B, Li J, Hu Y, Li P (2022) Is there an association between recurrent spontaneous abortion and mycoplasma infection?. J Infect Dev Ctries 16:1302-1307. doi: 10.3855/jidc.15134
Section
Original Articles