Pneumocystis jirovecii colonization in bronchoalveolar lavage among naïve non-small cell lung cancer from tertiary respiratory hospital in Jakarta, Indonesia

  • Jamal Zaini Department of Pulmonology and Respiratory Medicine Faculty of Medicine Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia https://orcid.org/0000-0002-3573-6312
  • Abul A’la Al Maududi Department of Pulmonology and Respiratory Medicine Faculty of Medicine Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia
  • Tasya Fillahihasanah Department of Pulmonology and Respiratory Medicine Faculty of Medicine Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia
  • Muhamad Rizqy Fadhillah Department of Pulmonology and Respiratory Medicine Faculty of Medicine Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia
  • Prasenohadi Pradono Department of Pulmonology and Respiratory Medicine Faculty of Medicine Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia
  • Budi Haryanto Microbiology Unit, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia
  • Robiatul Adawiyah Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
  • Findra Setianingrum Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
  • Anna Rozaliyani Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia https://orcid.org/0000-0002-6616-8565
  • Elisna Syahruddin Department of Pulmonology and Respiratory Medicine Faculty of Medicine Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia
Keywords: Pneumocystis jirovecii, bronchoalveolar lavage, lung neoplasms

Abstract

Introduction: Pneumocystis jirovecii pneumonia (PJP) is a lung mycosis commonly found in immunocompromised patients (e.g., HIV patients); however, its role in solid cancer remains unclear. This study aims to identify Pneumocystis jirovecii colonization among naïve non-small-cell lung cancer (NSCLC) through bronchoalveolar lavage (BAL) and explore its correlation with clinical parameters.

Methodology: This cross-sectional study recruited newly diagnosed naïve NSCLC patients who had not been given systemic treatments. We tested BAL from patients for P. jirovecii colonization with nested PCR targeting the mtLSU rRNA gene. Demographic and clinical characteristics were obtained from medical records, and the correlation between P. jirovecii colonization and clinicopathological data were analyzed. Kaplan-Meier analyses were done to evaluate survival.

Results: Among 56 newly diagnosed, naïve NSCLC patients enrolled, the prevalence of P. jirovecii colonization was 17.9% (10 subjects). There was no statistically significant difference in demographic and clinical characteristics between the P. jirovecii colonization group versus no colonization (p value > 0.05). The overall survival duration for both groups demonstrated no significant difference.

Conclusions: This study demonstrated a relatively high prevalence of P. jirovecii colonization among BAL samples of naïve Indonesian NSCLC patients. Further study is needed to delineate its implications for the potential transmission source, lung cancer pathogenesis, and prognosis.

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Published
2022-10-31
How to Cite
1.
Zaini J, A’la Al MaududiA, Fillahihasanah T, Rizqy FadhillahM, Pradono P, Haryanto B, Adawiyah R, Setianingrum F, Rozaliyani A, Syahruddin E (2022) Pneumocystis jirovecii colonization in bronchoalveolar lavage among naïve non-small cell lung cancer from tertiary respiratory hospital in Jakarta, Indonesia. J Infect Dev Ctries 16:1643-1647. doi: 10.3855/jidc.15840
Section
Brief Original Articles

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