PNI, NLR and PLR combined detection prognosis of patients with chronic hepatitis C-associated cirrhosis complicated by T2DM

Dong Wu; Xiaowu Wang; Yunyun Ding; Yan Liu; Tuantuan Li; Yi lang Zhu; Yong Gao; Xiaojuan Wang

doi:10.3855/jidc.18157

PNI, NLR and PLR combined detection prognosis of patients with chronic hepatitis C-associated cirrhosis complicated by T2DM

Authors

Dong Wu Department of Pharmacy, Fuyang People's Hospital, Fuyang, Anhui, China
Xiaowu Wang Department of Clinical Laboratory, The Second People's Hospital of Fuyang, Fuyang. Fuyang infection Disease Clinical College of Anhui Medical university, Anhui, China
Yunyun Ding Department of Clinical Laboratory, The Second People's Hospital of Fuyang, Fuyang. Fuyang infection Disease Clinical College of Anhui Medical university, Anhui, China
Yan Liu Department of Clinical Laboratory, The Second People's Hospital of Fuyang, Fuyang. Fuyang infection Disease Clinical College of Anhui Medical university, Anhui, China
Tuantuan Li Department of Clinical Laboratory, The Second People's Hospital of Fuyang, Fuyang. Fuyang infection Disease Clinical College of Anhui Medical university, Anhui, China
Yi lang Zhu Department of Clinical Laboratory, The Second People's Hospital of Fuyang, Fuyang. Fuyang infection Disease Clinical College of Anhui Medical university, Anhui, China
Yong Gao Department of Clinical Laboratory, The Second People's Hospital of Fuyang, Fuyang. Fuyang infection Disease Clinical College of Anhui Medical university, Anhui, China
Xiaojuan Wang Department of Pharmacy, Fuyang People's Hospital, Fuyang, Anhui, China https://orcid.org/0000-0002-9215-5733

DOI:

https://doi.org/10.3855/jidc.18157

Keywords:

Prognostic nutrition index, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, chronic hepatitis C-associated cirrhosis, T2DM

Abstract

Introduction: The prognostic nutrition index (PNI), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) have been studied widely in the context of cancer; however, their correlation with chronic hepatitis C-associated cirrhosis complicated by type 2 diabetes mellitus (T2DM) is unknown.

Aim: To investigate the correlation of the PNI, NLR, and PLR with chronic hepatitis C-associated cirrhosis complicated by T2DM.

Methodology: We investigated 226 patients, comprising 56 patients with chronic hepatitis C-associated cirrhosis complicated by T2DM mellitus (group A), 85 patients with chronic hepatitis C-associated cirrhosis (group B), and 85 patients with T2DM (group C). The baseline data of all patients were analyzed.

Results: A comparison of baseline data among the three groups showed significant differences in age (p = 0.008). The levels of PNI were different among the three groups (p < 0.01). The NLR, PNI, and PLR were significantly different between the good and poor prognosis groups (p < 0.05). The AUC for the combined determination of PNI, NLR, and PLR, showed excellent diagnostic performance (AUC = 0.911, 95% CI 0.741—0.985, sensitivity = 80.00 %, and specificity = 88.89%).

Conclusions: The PNI, NLR, and PLR were closely related to the prognosis of chronic hepatitis C-associated cirrhosis complicated by T2DM, and their combined detection had the highest specificity and sensitivity for the early prediction of the poor prognosis of chronic hepatitis C-associated cirrhosis complicated by T2DM, which has important clinical value.

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Published

2023-10-31

How to Cite

Wu D, Wang X, Ding Y, Liu Y, Li T, Zhu Y lang, Gao Y, Wang X (2023) PNI, NLR and PLR combined detection prognosis of patients with chronic hepatitis C-associated cirrhosis complicated by T2DM. J Infect Dev Ctries 17:1356–1361. doi: 10.3855/jidc.18157

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Issue

Vol. 17 No. 10: October 2023

Section

Emerging Problems in Infectious Diseases

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