Utility of bone marrow examination (BME) in the diagnosis of pyrexia of unknown origin (PUO)

Authors

  • Kanne Padmaja Department of Microbiology, Nizam’s Institute of Medical Sciences, Punjagutta, Hyderabad 500082, Telangana, India https://orcid.org/0000-0002-7780-6067
  • Syeda Saba Hashmiya Department of Microbiology, Nizam’s Institute of Medical Sciences, Punjagutta, Hyderabad 500082, Telangana, India https://orcid.org/0009-0005-2274-6190
  • Sukanya Sudhaharan Department of Microbiology, Nizam’s Institute of Medical Sciences, Punjagutta, Hyderabad 500082, Telangana, India https://orcid.org/0000-0002-2272-2640
  • Vijay Dharma Teja Department of Microbiology, Nizam’s Institute of Medical Sciences, Punjagutta, Hyderabad 500082, Telangana, India https://orcid.org/0000-0003-2642-9932
  • Madhusudhan Patil Department of Microbiology, Nizam’s Institute of Medical Sciences, Punjagutta, Hyderabad 500082, Telangana, India
  • Shantveer Uppin Department of Pathology, Nizam’s Institute of Medical Sciences, Punjagutta, Hyderabad 500082, Telangana, India
  • Malladi Venkata Surya Subbalaxmi Department of Medicine, Nizam’s Institute of Medical Sciences, Punjagutta, Hyderabad 500082, Telangana, India

DOI:

https://doi.org/10.3855/jidc.17367

Keywords:

pyrexia, granuloma, immunocompromised, bacterial, mycobacterial

Abstract

Introduction: Bone marrow examination (BME) is a useful tool in the diagnosis of haematological and non-haematological diseases. It plays an important role in early diagnosis of the underlying cause of pyrexia of unknown origin (PUO) and can influence the management of patients. Bone marrow aspiration (BMA) plays a very important role in establishing a definitive diagnosis in cases of PUO. The aim of this study was to review the indications and usefulness of bone marrow aspirates sent for microbiological evaluation as a diagnostic tool with histopathological correlation.

Methodology: A prospective study was conducted from 1 January 2017 to 30 September 2019 in the Department of Microbiology and Pathology on the bone marrow aspirates of patients of all groups.

Results: A total of 148 bone marrow aspirates were included. The cases were categorized as classical PUO (n = 81/148, 54.7%), nosocomial PUO (n = 4 /148, 2.7%), neutropenic PUO (n = 18/148, 12.1%), and immunocompromised PUO (n = 45/148, 30.4%), among which were systemic lupus erythematosus cases n = 8/45 (22.2%), human immunodeficiency virus positive cases n = 10/45 (17.7%), and renal transplant cases n = 27/45 (60%). A total of 28 BMAs were positive for microorganisms, out of which bacterial pathogens were n = 12 (42.8%), mycobacterial n = 12, 42.8%, fungal (n = 3, 10.7 %), and viruses (n = 1, 3.5%).

Conclusions: This study helped in highlighting the role of bone marrow examination as an important diagnostic method in the diagnosis of infectious diseases.

Author Biographies

Kanne Padmaja, Department of Microbiology, Nizam’s Institute of Medical Sciences, Punjagutta, Hyderabad 500082, Telangana, India

Associate Professor,Dept. Of Microbiology

Sukanya Sudhaharan, Department of Microbiology, Nizam’s Institute of Medical Sciences, Punjagutta, Hyderabad 500082, Telangana, India

Associate Professor,Dept. Of Microbiology

Vijay Dharma Teja, Department of Microbiology, Nizam’s Institute of Medical Sciences, Punjagutta, Hyderabad 500082, Telangana, India

Professor and HOD, Dept. Of Microbiology

Madhusudhan Patil, Department of Microbiology, Nizam’s Institute of Medical Sciences, Punjagutta, Hyderabad 500082, Telangana, India

Additional Professor, Dept. Of Microbiology

Shantveer Uppin, Department of Pathology, Nizam’s Institute of Medical Sciences, Punjagutta, Hyderabad 500082, Telangana, India

Professor and HOD, Dept. Of  Pathology

Malladi Venkata Surya Subbalaxmi, Department of Medicine, Nizam’s Institute of Medical Sciences, Punjagutta, Hyderabad 500082, Telangana, India

Additional Professor, Dept. Of Medicine

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Published

2023-12-31

How to Cite

1.
Padmaja K, Hashmiya SS, Sudhaharan S, Teja VD, Patil M, Uppin S, Subbalaxmi MVS (2023) Utility of bone marrow examination (BME) in the diagnosis of pyrexia of unknown origin (PUO). J Infect Dev Ctries 17:1798–1805. doi: 10.3855/jidc.17367

Issue

Vol. 17 No. 12: December 2023

Section

Original Articles

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Copyright (c) 2023 Kanne Padmaja, Syeda Saba Hashmiya, Sukanya Sudhaharan, Vijay Dharma Teja , Madhsudhan Patil, Shantveer Uppin, Malladi Venkata Surya Subbalaxmi

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