Seroprevalence of Hepatitis B virus and human immunodeficiency virus co-infection in pregnant women from Osun State, Nigeria

Ifeoluwa O Bejide; Tolulope A Kayode; Angel E Ebagua; Oghenetega D Obayendo; Divine O Mere; Abasianam B Newman; Amarachukwu M Obi-Odunukwe; Ademola K Fadare; Muhammad I Ahmed; Temitope M Adeyemi-Kayode; Onikepe A Folarin

doi:10.3855/jidc.18704

Seroprevalence of Hepatitis B virus and human immunodeficiency virus co-infection in pregnant women from Osun State, Nigeria

Authors

Ifeoluwa O Bejide Viral Hepatitis Research Cluster, Redeemer’s University, Ede Osun State, Nigeria https://orcid.org/0000-0002-8263-9064
Tolulope A Kayode Viral Hepatitis Research Cluster, Redeemer’s University, Ede Osun State, Nigeria https://orcid.org/0000-0003-4249-9850
Angel E Ebagua Department of Biological Sciences, Redeemer’s University, Ede Osun State, Nigeria
Oghenetega D Obayendo Department of Biological Sciences, Redeemer’s University, Ede Osun State, Nigeria
Divine O Mere Department of Biological Sciences, Redeemer’s University, Ede Osun State, Nigeria https://orcid.org/0009-0001-1299-9689
Abasianam B Newman Department of Biological Sciences, Redeemer’s University, Ede Osun State, Nigeria https://orcid.org/0000-0001-7831-1544
Amarachukwu M Obi-Odunukwe Department of Biological Sciences, Redeemer’s University, Ede Osun State, Nigeria
Ademola K Fadare Department of Biological Sciences, Redeemer’s University, Ede Osun State, Nigeria https://orcid.org/0009-0006-6668-198X
Muhammad I Ahmed African Centre of Excellence for Genomics of Infectious Diseases, Redeemer’s University, Ede Osun State, Nigeria https://orcid.org/0000-0002-7679-5052
Temitope M Adeyemi-Kayode Department of Biological Sciences, University of Notre Dame, South Bend, IN, United States
Onikepe A Folarin Department of Biological Sciences, Redeemer’s University, Ede Osun State, Nigeria https://orcid.org/0000-0001-7283-2920

DOI:

https://doi.org/10.3855/jidc.18704

Keywords:

seroprevalence, ELISA, HBV/HIV, co-infection, pregnant women, Nigeria

Abstract

Introduction: Hepatitis B virus and human immunodeficiency virus (HBV/HIV) co-infection is a global health concern due to its significant impact on morbidity and mortality. Reports of HBV/HIV co-infections are increasing in Nigeria, but information on the disease burden in pregnant women and its implications on the fetus is scarce. This study aimed to determine the prevalence of HBV/HIV co-infection in pregnant women. In addition, the study identified the risk factors for the disease in pregnant women attending antenatal clinics in Osun State, Nigeria.

Methodology: We collected plasma samples from 303 consenting pregnant women and used enzyme-linked immunosorbent assay (ELISA) to test for HBV (HBsAg) and HIV I/II antigens. We obtained demographic and risk factor data on HBV and HIV transmission using a structured questionnaire.

Results: Our analysis revealed a prevalence of 3.96% for HBV/HIV co-infection in pregnant women. Bivariate analysis indicated a history of blood transfusion, oral or anal sex, and multiple sexual partners may be associated with an increased likelihood of HBV/HIV co-infection in pregnant women. After adjusting for other variables in multivariate analysis, none of these risk factors were significant at the 5% level. In contrast, formal education was a potential preventive factor in this population.

Conclusions: Our study provides valuable information on the disease burden of HBV/HIV co-infection in pregnant women in Osun State, Nigeria, highlighting the importance of routine screening for HBV and HIV during antenatal care and emphasizing the importance of implementing preventive measures to reduce the morbidity and mortality associated with HBV/HIV co-infection.

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Published

2024-01-31

How to Cite

Bejide IO, Kayode TA, Ebagua AE, Obayendo OD, Mere DO, Newman AB, Obi-Odunukwe AM, Fadare AK, Ahmed MI, Adeyemi-Kayode TM, Folarin OA (2024) Seroprevalence of Hepatitis B virus and human immunodeficiency virus co-infection in pregnant women from Osun State, Nigeria. J Infect Dev Ctries 18:145–151. doi: 10.3855/jidc.18704

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Issue

Vol. 18 No. 01: January 2024

Section

Original Articles

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Copyright (c) 2024 Ifeoluwa O Bejide, Tolulope A Kayode, Angel E Ebagua, Oghenetega D Obayendo, Divine O Mere, Abasianam B Newman, Amarachukwu M Obi-Odunukwe, Ademola K Fadare, Muhammad I Ahmed, Temitope M Adeyemi-Kayode, Onikepe A Folarin

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