Metagenomic next-generation sequencing confirmed a case of sporadic human infection with Streptococcus suis in an urban area

Youwen Ye; Huajie Gu; Tianyu Li; Xiaoyong Dai; Bin Shi

doi:10.3855/jidc.18805

Metagenomic next-generation sequencing confirmed a case of sporadic human infection with Streptococcus suis in an urban area

Authors

Youwen Ye Department of Emergency Intensive Care Unit, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, China https://orcid.org/0000-0001-6765-3207
Huajie Gu Department of Emergency Intensive Care Unit, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, China https://orcid.org/0009-0009-2147-2545
Tianyu Li Genoxor Medical Science and Technology Inc., Shanghai, China https://orcid.org/0009-0008-4648-3286
Xiaoyong Dai Department of Emergency Intensive Care Unit, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, China https://orcid.org/0009-0006-8065-1111
Bin Shi Department of Emergency Intensive Care Unit, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, China https://orcid.org/0009-0006-0392-1309

DOI:

https://doi.org/10.3855/jidc.18805

Keywords:

Streptococcus suis, zoonosis, meningitis, metagenome, mNGS

Abstract

Introduction: Streptococcus suis (S. suis) disease is a zoonotic infection caused by invasive S. suis and can lead to meningitis, septic shock, arthritis, and endocarditis. Early treatment is the key to reducing mortality. However, clinical manifestations of most cases are atypical, severely limiting rapid diagnosis and treatment.

Case report: Here, we report a 74-year-old female patient diagnosed with S. suis infection. The main symptoms were hearing loss, lumbago, and scattered ecchymosis of the lower extremities and trunk. Blood non-specific infection indexes were significantly increased and platelets were significantly decreased; however, no pathogens were obtained from routine blood culture. Finally, the S. suis infection was confirmed by metagenomic next-generation sequencing (mNGS) of blood and cerebrospinal fluid. After antibiotic treatment, the limb and trunk scattered ecchymosis and lumbago symptoms were significantly relieved, but the hearing did not recover.

Conclusions: Human infection with S. suis is rare in central cities, and it is easy to misdiagnose, especially in cases with atypical early symptoms. mNGS technology, combined with clinical observation, is helpful to clarify the direction of diagnosis and treatment, which is conducive to patient recovery.

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Published

2024-04-30

How to Cite

Ye Y, Gu H, Li T, Dai X, Shi B (2024) Metagenomic next-generation sequencing confirmed a case of sporadic human infection with Streptococcus suis in an urban area. J Infect Dev Ctries 18:645–650. doi: 10.3855/jidc.18805

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Issue

Vol. 18 No. 04: April 2024

Section

Case Reports

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