Side effects of COVID-19 vaccines among Iranian healthcare workers: a retrospective cohort study

Authors

  • Hassan Roudgari Department of Research, IR Iran Medical Council, Genomic Research Center, National Center for Genomic Excellence, Shahid Beheshti University of Medical Sciences, Tehran, Iran https://orcid.org/0000-0002-8078-5850
  • Koorosh Etemad Department of Epidemiology, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Manoochehr Karami Department of Epidemiology, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Farideh Mostafavi Department of Epidemiology, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Sahar Sotoodeh Ghorbani Department of Epidemiology, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Kosar Farhadi Babadi Department of Epidemiology, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Elham Rahimi Department of Epidemiology, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Niloufar Taherpour Department of Epidemiology, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Seyed Mahmood Fattahi Masoom Chief Executive Officer, NOBAAN Private Corporation, Tehran, Iran
  • Masoud Habibi Department of Photo Healing and Regeneration, Medical Laser Research Center, Yara Institute, ACECR, Tehran, Iran
  • Hossein Kermanpour Emergency Department, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
  • Reza Laripour Department of Education, Aja University of Medical Sciences, Tehran, Iran
  • Omid Manoochehri Chairman of the Board, NOBAAN Private Corporation, Tehran, Iran
  • Mohammad Raeeszadeh Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran
  • Alireza Salimi Chronic Respiratory Diseases Research Center, Anesthesia and Critical Care Department, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Babak Shekarchi Department of Radiology, School of Medicine, AJA University of Medical Sciences, Tehran, Iran
  • Ali Tajernia Iranian Dental Association, Tehran, Iran
  • Mohammad Reza Zafarghandi Department of Vascular Surgery and Traumatology, Sina General Hospital, Tehran University of Medical Sciences, Tehran, Iran
  • Alireza Zali Functional Neurosurgery Research Center, Shohada Tajrish Neurosurgical Center of Excellence, Shohada Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Afshin Zarghi Department of Medicinal and Pharmaceutical Chemistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Seyed Saeed Hashemi Nazari Prevention of Cardiovascular Disease Research Center, Department of Epidemiology, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran

DOI:

https://doi.org/10.3855/jidc.17691

Keywords:

side effects, vaccine, COVID-19, healthcare workers

Abstract

Introduction: This study assessed the incidence and severity of side effects associated with coronavirus disease 2019 (COVID-19) vaccination among healthcare workers registered with the Medical Council of the Islamic Republic of Iran.

Methodology: A retrospective cohort study was conducted on the healthcare workers focusing on the side-effects of COVID-19 vaccines from March to June 2021. Data were collected using online questionnaires. Multivariable logistic regression was used to assess the association between side effects of the vaccines and demographic variables, comorbidities, vaccine type, and history of COVID-19.

Results: Out of 42,018 people who were included, 55.85% reported at least one side effect after receiving the first vaccine dose. 4.59% of those with side effects sought diagnostic intervention or were referred to treatment centers. Multivariable logistic regression indicated that being a woman, higher education, having a history of COVID-19 infection, and having comorbidities increased the risk of side effects. The AstraZeneca vaccine significantly increased the risk of side effects compared to the Sputnik vaccine, while the Sinopharm vaccine decreased this risk. The risk of developing a side effect decreased with age. The risk of moderate and severe side effects was significantly associated with gender, younger age, comorbidities, and a history of COVID-19 infection. Moderate and severe side effects were less reported by those who received the Sinopharm vaccine.

Conclusions: Clinical complications after COVID-19 vaccination, directly or indirectly caused by the vaccines, are common. However, the benefits of COVID-19 vaccines greatly outweigh the risk of reversible side effects, especially among the high-risk population.

Author Biographies

Omid Manoochehri, Chairman of the Board, NOBAAN Private Corporation, Tehran, Iran

 

 

 

 

Mohammad Raeeszadeh, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran

 

 

 

Alireza Salimi, Chronic Respiratory Diseases Research Center, Anesthesia and Critical Care Department, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

 

 

 

Babak Shekarchi, Department of Radiology, School of Medicine, AJA University of Medical Sciences, Tehran, Iran

 

 

 

Ali Tajernia, Iranian Dental Association, Tehran, Iran

 

 

 

Mohammad Reza Zafarghandi, Department of Vascular Surgery and Traumatology, Sina General Hospital, Tehran University of Medical Sciences, Tehran, Iran

 

 

 

Alireza Zali, Functional Neurosurgery Research Center, Shohada Tajrish Neurosurgical Center of Excellence, Shohada Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

 

 

 

Afshin Zarghi, Department of Medicinal and Pharmaceutical Chemistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran

 

 

 

Seyed Saeed Hashemi Nazari, Prevention of Cardiovascular Disease Research Center, Department of Epidemiology, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran

 

Affiliation:

Email: 

Downloads

Published

2024-04-30

How to Cite

1.
Roudgari H, Etemad K, Karami M, Mostafavi F, Sotoodeh Ghorbani S, Farhadi Babadi K, Rahimi E, Taherpour N, Fattahi Masoom SM, Habibi M, Kermanpour H, Laripour R, Manoochehri O, Raeeszadeh M, Salimi A, Shekarchi B, Tajernia A, Zafarghandi MR, Zali A, Zarghi A, Hashemi Nazari SS (2024) Side effects of COVID-19 vaccines among Iranian healthcare workers: a retrospective cohort study. J Infect Dev Ctries 18:532–541. doi: 10.3855/jidc.17691

Issue

Vol. 18 No. 04: April 2024

Section

Coronavirus Pandemic

License

Copyright (c) 2024 Dr Hassan Roudgari, Dr Koorosh Etemad, Dr Manoochehr Karami , Dr Farideh Mostafavi , Ms Sahar Sotoodeh Ghorbani, Ms Kosar Farhadi Babadi , Ms Elham Rahimi , Ms Niloufar Taherpour , Dr Seyed Mahmood Fattahi Masoom , Dr Masoud Habibi , Dr Hossein Kermanpour , Dr Reza Laripour , Dr Omid Manoochehri , Dr Mohammad Raeeszadeh , Dr Alireza Salimi , Dr Babak Shekarchi , Dr Ali Tajernia , Dr Mohammad Reza Zafarghandi , Dr Alireza Zali , Dr Afshin Zarghi , Dr Seyed Saeed Hashemi Nazari

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
Crossref
Scopus
Google Scholar
Europe PMC