Evaluation of infants administered prophylactic intravenous immunoglobulin following exposure to measles

Canan Caymaz; Ahmet Soysal; Işıl Maral; Rengin Şiraneci; Ümmü Hatipoğlu; Perihan Alkan; Esat Rıdvan Dikleli; Ali Alptekin; Ateş Kara; Mustafa Taşdemir

doi:10.3855/jidc.18701

Evaluation of infants administered prophylactic intravenous immunoglobulin following exposure to measles

Authors

Canan Caymaz Division of Pediatric Infectious Diseases, Department of Pediatrics, Basaksehir Cam and Sakura City Hospital, Health Sciences University, Istanbul, Turkey https://orcid.org/0000-0003-0990-7904
Ahmet Soysal Memorial Atasehir Hospital, Division of Pediatric Infectious Diseases, Istanbul, Turkey
Işıl Maral Department of Public Health, Istanbul Medeniyet University Faculty of Medicine, Istanbul, Turkey
Rengin Şiraneci Emeritus, Division of Pediatric Infectious Diseases, Department of Pediatrics, Kanuni Sultan Suleiman Training and Research Hospital, Istanbul, Turkey
Ümmü Hatipoğlu Bursa Provincial Health Directorate, Nilüfer County Health Department, Bursa, Turkey
Perihan Alkan Istanbul Provincial Health Directorate, Public Health Services Department, Communicable Diseases Unit, Istanbul, Turkey
Esat Rıdvan Dikleli Turkish Airlines, Occupational Health Directorate, Istanbul, Turkey
Ali Alptekin Istanbul Provincial Health Directorate, Istanbul, Turkey
Ateş Kara Department of Pediatric Infectious Diseases, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey https://orcid.org/0000-0002-1654-3232
Mustafa Taşdemir Emeritus, Department of Public Health, Istanbul Medeniyet University Faculty of Medicine, Istanbul, Turkey

DOI:

https://doi.org/10.3855/jidc.18701

Keywords:

Measles, immunoglobulin, post-exposure prophylaxis, infant

Abstract

Introduction: Intravenous immunoglobulin (IVIG) is an alternative for post-exposure prophylaxis if a vaccine is contraindicated and intramuscular immunoglobulin is unavailable. We retrospectively examined the effect of IVIG administration time on measles development in measles-contact infants younger than 6 months of age.

Methodology: Contact tracing of measles cases was performed by the Istanbul Public Health Directorate (IPHD) between August 24, 2012, and June 16, 2013. The mothers of 187 infants younger than 6 months were found to have negative IgG for measles. Under IPHD supervision, IVIG (0.4 g/kg) was administered to these infants within the first 6-10 days following exposure. These infants were monitored for rash and fever by IPHD for up to 28 days after IVIG prophylaxis. The study was conducted retrospectively, infants were divided into two groups, those who received IVIG at 6 days and later. These groups were compared according to the development of measles.

Results: Only 2 out of 187 infants developed measles after IVIG prophylaxis. No significant difference in measles frequency was observed between infants who received IVIG within the first 6 days after exposure and those who received IVIG after 6 days. Nine infants received IVIG in the first 3 days, and none of them developed measles. The risk of developing measles was higher in infants who had experienced contact at home (p = 0.002).

Conclusion: IVIG administration may provide stronger protection in the first 3 days and may be given until 10 days after exposure.

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Published

2024-11-30

How to Cite

Caymaz C, Soysal A, Maral I, Şiraneci R, Hatipoğlu Ümmü, Alkan P, Dikleli ER, Alptekin A, Kara A, Taşdemir M (2024) Evaluation of infants administered prophylactic intravenous immunoglobulin following exposure to measles. J Infect Dev Ctries 18:1739–1745. doi: 10.3855/jidc.18701

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Issue

Vol. 18 No. 11: November 2024

Section

Original Articles

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