OXA-48-producing Enterobacteriaceae in North of Morocco: Data from regional hospital of Tangier

Authors

  • Younes Mahrach Higher Institute of Nursing Professions and Technical Health of Tangier, Morocco https://orcid.org/0009-0002-4823-5266
  • Nadira Mourabit Laboratory of Research and Development in Engineering Sciences, Faculty of Sciences and Techniques of Al-Hoceima, Abdelmalek Essaadi University, Tetouan, Morocco
  • Mohamed Bakkali Biotechnology and Biomolecule Engineering Research Laboratory, Faculty of Sciences and Techniques of Tangier, Abdelmalek Essaadi University, Tetouan, Morocco
  • Abdelhay Arakrak Biotechnology and Biomolecule Engineering Research Laboratory, Faculty of Sciences and Techniques of Tangier, Abdelmalek Essaadi University, Tetouan, Morocco https://orcid.org/0000-0002-7019-6649
  • Amine Laglaoui Biotechnology and Biomolecule Engineering Research Laboratory, Faculty of Sciences and Techniques of Tangier, Abdelmalek Essaadi University, Tetouan, Morocco

DOI:

https://doi.org/10.3855/jidc.18564

Keywords:

Carbapebemases, Morocco, OXA-48, antimicrobial resistance

Abstract

Introduction: This is a three-year retro-prospective study aimed at assessing the prevalence of carbapenem-resistant Enterobacteriaceae and to study three-year retrospective study aimed at determining the prevalence of carbapenem-resistant Enterobacteriaceae and analyzing the characteristics of OXA-48 producers.

Methodology: Six thousand one hundred eighteen bacteriological samples were assessed at Mohamed V Regional Hospital microbiology laboratory in Tangier, Morocco.

Results: Of the 1,228 identified Enterobacteriaceae, Escherichia coli was the most isolated bacteria (68%). Fifty-eight Enterobacteriaceae were resistant to carbapenem (4.7%). Klebsiella pneumoniae, Escherichia coli, and Enterobacter cloacae were the most common carbapenemase-producing isolates (43.1%, 27.5%, and 20.7%, respectively). All isolates were resistant to ertapenem, 62% to imipenem, whereas the lowest rate of resistance to carbapenems was against meropenem (51%). Among carbapenemase-producing isolates, 13.8% also produced extended-spectrum beta-lactamase. Most carbapenemase-producing Enterobacteriaceae isolates harbored the gene blaOXA-48 (84.5%).

Conclusions: Our findings highlight the alarming situation of the probable misuse of antibiotics. Awareness-raising sessions about the appropriate use of antibiotics and improving hospital hygiene are highly needed.

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Published

2025-01-31

How to Cite

1.
Mahrach Y, Mourabit N, Bakkali M, Arakrak A, Laglaoui A (2025) OXA-48-producing Enterobacteriaceae in North of Morocco: Data from regional hospital of Tangier. J Infect Dev Ctries 19:83–90. doi: 10.3855/jidc.18564

Issue

Vol. 19 No. 01: January 2025

Section

Original Articles

License

Copyright (c) 2025 Younes Mahrach, Nadira Mourabit, Mohammed Bakkali, Abdelhay Arakrak, Amine Laglaoui

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