Decreased albumin to INR ratio is a prognostic marker of 30-day mortality in neonatal sepsis: a retrospective study

Xiangwen Tu; Junkun Chen; Wen Liu

doi:10.3855/jidc.20968

Decreased albumin to INR ratio is a prognostic marker of 30-day mortality in neonatal sepsis: a retrospective study

Authors

Xiangwen Tu Laboratory of Eugenics Genetics, Ganzhou Women and Children's Health Care Hospital, Ganzhou, Jiangxi, China
Junkun Chen Laboratory of Eugenics Genetics, Ganzhou Women and Children's Health Care Hospital, Ganzhou, Jiangxi, China
Wen Liu Neonatal intensive care Unit, Ganzhou Women and Children's Health Care Hospital, Ganzhou, Jiangxi, China https://orcid.org/0009-0006-5514-066X

DOI:

https://doi.org/10.3855/jidc.20968

Keywords:

Albumin, international normalized ratio, mortality, neonatal sepsis, prognosis

Abstract

Introduction: Neonatal sepsis is a leading cause of neonatal mortality. This study aims to assess the clinical significance of the serum albumin (ALB) to international normalized ratio (INR) ratio (AIR) as a predictor for 30-day mortality in neonates with sepsis.

Methodology: Neonates diagnosed with sepsis between January 2019 and December 2022 were included. Admission data were collected, enabling the categorization of neonates into survival and non-survival groups. Logistic regression analyses and receiver operating characteristic (ROC) curves, were employed.

Results: A total of 195 neonates with sepsis were analyzed. The non-survival group exhibited significantly lower AIR compared to the survival group. Multivariate analysis identified low AIR as an independent risk factor (hazard ratio [HR]: 9.091, p < 0.001), achieving an area under the curve (AUC) of 0.746 for AIR. The sensitivity and specificity of AIR were 79.31% and 66.87%, respectively.

Conclusions: AIR serves as a cost-effective and easily obtainable marker in neonatal sepsis research. It emerges as an independent predictor of adverse outcomes in neonatal sepsis, demonstrating good predictive capabilities.

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Published

2025-09-30

How to Cite

Tu X, Chen J, Liu W (2025) Decreased albumin to INR ratio is a prognostic marker of 30-day mortality in neonatal sepsis: a retrospective study. J Infect Dev Ctries 19:1370–1376. doi: 10.3855/jidc.20968

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Issue

Vol. 19 No. 09: September 2025

Section

Original Articles

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