Toxoplasmosis in immunocompromised patients in Iran: a systematic review and meta-analysis

  • Ehsan Ahmadpour Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari, Iran
  • Ahmad Daryani Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari, Iran
  • Mahdi Sharif Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari, Iran
  • Shahabeddin Sarvi Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari, Iran
  • Mohsen Aarabi Sari Medical School, Mazandaran University of Medical Sciences, Sari, Iran
  • Azadeh Mizani Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari, Iran
  • Mohammad Taghi Rahimi Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari, Iran
  • Azar Shokri Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari, Iran
Keywords: toxoplasmosis, immunocompromised, HIV/AIDS, cancer, transplant, Iran

Abstract

Although toxoplasmosis in immunocompetent individuals is generally asymptomatic, in immunocompromised patients (HIV/AIDS, cancer, and transplant patients), it can lead to serious pathological effects. This study included a systematic review and meta-analysis to comprehensively assess the seroprevalence rate of Toxoplasma infection in immunocompromised patients in Iran. Electronic English and Persian databases (PubMed, Google Scholar, ScienceDirect, Scopus, Magiran, Scientific Information Database [SID], IranMedex, and IranDoc), parasitology congresses, and projects and theses of Iranian medical universities, were systematically searched from 1997 to 2013 (published or unpublished data). In this paper, several studies that used serological methods for diagnosis of toxoplasmosis were selected. Analysis of seroprevalence estimates was pooled using a random-effects meta-analysis. Twenty-two studies, comprising 2,805 individuals, were included in the meta-analysis. Overall seroprevalence rate of Toxoplasma infection in Iranian immunocompromised patients was 50.01% (95% confidence interval, 43.85 to 56.17); however, there was significant heterogeneity among study groups. The results showed that seroprevalence rate of toxoplasmosis among transplant recipients, HIV/AIDS, and cancer patients in Iran was 55.1%, 50.05%, and 45.06%, respectively. In addition, IgM seroprevalence rate was estimated to be 4.85% (95% confidence interval, 2.22 to 8.41). This systematic review and meta-analysis identified a high seroprevalence rate of Toxoplasma infection among immunocompromised patients (50%).Consideration of management , design and provision of appropriate control measures of toxoplasmosis is highly recommended.

Author Biographies

Ehsan Ahmadpour, Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari, Iran
Ph.D student of parasitologyDepartment of Parasitology and Mycology, SariMedical School, Mazandaran University of Medical Sciences 
Ahmad Daryani, Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari, Iran
Professor in medical parasitologyDepartment of Parasitology and Mycology, SariMedical School, Mazandaran University of Medical Sciences
Mahdi Sharif, Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari, Iran
Professor in medical parasitologyDepartment of Parasitology and Mycology, SariMedical School, Mazandaran University of Medical Sciences
Shahabeddin Sarvi, Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari, Iran
Assistant professorDepartment of Parasitology and Mycology, SariMedical School, Mazandaran University of Medical Sciences
Mohsen Aarabi, Sari Medical School, Mazandaran University of Medical Sciences, Sari, Iran
Assistant professorSari Medical School, Mazandaran University of Medical Sciences
Azadeh Mizani, Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari, Iran
Ph.D student of parasitologyDepartment of Parasitology and Mycology, SariMedical School, Mazandaran University of Medical Sciences
Mohammad Taghi Rahimi, Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari, Iran
Ph.D student of parasitologyDepartment of Parasitology and Mycology, SariMedical School, Mazandaran University of Medical Sciences
Azar Shokri, Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari, Iran
Ph.D student of parasitologyDepartment of Parasitology and Mycology, SariMedical School, Mazandaran University of Medical Sciences
Published
2014-12-15
How to Cite
1.
Ahmadpour E, Daryani A, Sharif M, Sarvi S, Aarabi M, Mizani A, Rahimi M, Shokri A (2014) Toxoplasmosis in immunocompromised patients in Iran: a systematic review and meta-analysis. J Infect Dev Ctries 8:1503-1510. doi: https://doi.org/10.3855/jidc.4796
Section
Regional Reviews