Immune response to hepatitis B vaccine among north Iranian healthcare workers and its related factors

  • Farahnaz Joukar Guilan University of Medical Sciences, Rasht, Iran
  • Fariborz Mansour-Ghanaei Guilan University of Medical Sciences, Rasht, Iran
  • Mohammad Reza Naghipour Guilan University of Medical Sciences, Rasht, Iran
  • Mehrnaz Asgharnezhad Guilan University of Medical Sciences, Rasht, Iran

Abstract

Introduction: Hepatitis B virus (HBV) is an important occupational risk among healthcare workers (HCWs). Vaccination is the most cost-effective method of preventing and controlling HBV infection. Several factors have been suggested to effect response to the vaccine. The present study aimed to evaluate vaccine response among north Iranian HCWs and to determine the factors influencing vaccine response.


Methodology: Response to the standard three-dose vaccination regimen was evaluated in term of anti-hepatitis B surface antigen level among 1,010 HCWs using an enzyme-linked immunosorbent assay (ELISA) method. Logistic regression was applied to predict antibody response, with related factors including sex, age, years of working experience, marital status, history of transfusion, smoking, history of needle stick injury, rheumatic disease, steroid use, and elapsed time from vaccination measurement.


Results: Of the 1,010 HCWs, 898 (88.9%) acquired protective levels of antibody (> 10 IU/mL). Compared with those < 30 years of age, HCWs older than 50 years and between 40 and 50 years of age were more likely to have non-protective anti-HBs levels (odds ratio = 4.48; p = 0.001 and odds ratio = 1.85; p = 0.03, respectively).


Conclusions: HBV vaccine efficacy and immune response were satisfactory among north Iranian HCWs. Since it is predicted that anti-HBs levels decrease with aging, testing for anti-HBs titer is desirable for HCWs older than 50 years of age.

Author Biographies

Farahnaz Joukar, Guilan University of Medical Sciences, Rasht, Iran

PHD by Research student, Faculty member, Gastrointestinal & Liver Diseases Research Center (GLDRC)

Fariborz Mansour-Ghanaei, Guilan University of Medical Sciences, Rasht, Iran

Professor of Medicine, Gastrointestinal & Liver Diseases Research Center (GLDRC)

Mohammad Reza Naghipour, Guilan University of Medical Sciences, Rasht, Iran

Epidemiologist, Gastrointestinal & Liver Diseases Research Center (GLDRC),

Mehrnaz Asgharnezhad, Guilan University of Medical Sciences, Rasht, Iran

MS (Nursing), Researcher, Gastrointestinal & Liver Diseases Research Center (GLDRC)

Published
2017-06-27
How to Cite
Joukar F, Mansour-Ghanaei F, Naghipour M, Asgharnezhad M (2017) Immune response to hepatitis B vaccine among north Iranian healthcare workers and its related factors. The Journal Of Infection In Developing Countries 11 (06): 501-507. https://doi.org/10.3855/jidc.8182
Section
Brief Original Articles

Keywords

health care; virus titer; hepatitis B vaccineImmune; Response Antigens,