Active Surveillance of Influenza A and Other Respiratory Viruses in Children with Influenza-like-illness in Two Seasons

  • Saniye Girit Dr. Lütfi Kırdar Kartal Education and Research Hospital, Istanbul, Turkey
  • Ayşe Karaaslan Dr. Lütfi Kırdar Kartal Education and Research Hospital, Istanbul, Turkey
  • Serap Gençer Dr. Lütfi Kırdar Kartal Education and Research Hospital, Istanbul, Turkey
  • Emel Yılmaz Dr. Lütfi Kırdar Kartal Education and Research Hospital, Istanbul, Turkey
  • Yetkin Ayhan Dr. Lütfi Kırdar Kartal Education and Research Hospital, Istanbul, Turkey
  • Elif Ruşen Vayvada Dr. Lütfi Kırdar Kartal Education and Research Hospital, Istanbul, Turkey
  • Meral Akçay Ciblak Istanbul University, Istanbul, Turkey
  • Selim Badur Istanbul University, Istanbul, Turkey
  • Yasemin Akın Dr. Lütfi Kırdar Kartal Education and Research Hospital, Istanbul, Turkey
Keywords: Influenza A, Influenza like illness, influenza like illness, ILI, respiratory viruses

Abstract

Introduction: The aim of this study was to asses the surveillance of influenza A/other respiratory viruses and risk factors in hospitalized children with the symptoms of influenza-like illness during two consecutive influenza seasons.

Methodology: All children hospitalized with adiagnosis of influenza-like illness had been investigated for Influenza A and other respiratory antigens in pharengeal/nasopharyngeal secretions.

Results: A total of 132 hospitalized children between December 2013-May 2014 and December 2014-May 2015 were enrolled in this study. At least one respiratory virus was found to be positive by RT-PCR in 78 (59%) patients, influenza A (H3N2) was detected in only 8 (6%) patients. In 54 (41%) patients samples no respiratory viral pathogen was detected and in 70 (53%) patients, one non- influenza A virus was detected. The respiratory viral pathogens detected in decreasing rates were:RSV (n = 46, 35%), HCoV (n = 10, 7.5%), adenovirüs (n = 7, 5%), rhinovirüs (n = 6, 4.5%), HMPV (n = 5, 4%), Influenza B (n = 4, 3%) ve human Bocavirus (n = 2, 1.5%). In 10 patients, coinfection was detected, however none was with H3N2. In the H3N2 (+) group, the following risk factors were identified: age older than three years (p < 0.05), asthma history (p < 0.05) and chronic lung diseases (p < 0.05).

Conclusion: Influenza A virus was detected in 6% of hospitalized patients with influenza-like illness. Viruses other then Influenza, especially RSV, can cause similar symptoms compatible with Influenza-like-illness.

Author Biographies

Saniye Girit, Dr. Lütfi Kırdar Kartal Education and Research Hospital, Istanbul, Turkey

Department of Pediatrics, Division of Pediatric Pulmonology, Istanbul, Turkey

Ayşe Karaaslan, Dr. Lütfi Kırdar Kartal Education and Research Hospital, Istanbul, Turkey

Department of Pediatrics, Division of Pediatric Infectious Diseases, Istanbul,

Serap Gençer, Dr. Lütfi Kırdar Kartal Education and Research Hospital, Istanbul, Turkey

Department of Infectious Diseases and Clinical Microbiology, Istanbul, Turkey

Emel Yılmaz, Dr. Lütfi Kırdar Kartal Education and Research Hospital, Istanbul, Turkey

Department of Pediatrics, Istanbul, Turkey

Yetkin Ayhan, Dr. Lütfi Kırdar Kartal Education and Research Hospital, Istanbul, Turkey

Department of Pediatrics, Istanbul, Turkey

Elif Ruşen Vayvada, Dr. Lütfi Kırdar Kartal Education and Research Hospital, Istanbul, Turkey

Department of Pediatrics, Istanbul, Turkey

Meral Akçay Ciblak, Istanbul University, Istanbul, Turkey

Faculty of Medicine, Department of Microbiology, Istanbul, Turkey

Selim Badur, Istanbul University, Istanbul, Turkey

Faculty of Medicine, Department of Microbiology, Istanbul, Turkey

Yasemin Akın, Dr. Lütfi Kırdar Kartal Education and Research Hospital, Istanbul, Turkey

Department of Pediatrics, Istanbul, Turkey

Published
2018-01-10
How to Cite
1.
Girit S, Karaaslan A, Gençer S, Yılmaz E, Ayhan Y, Vayvada ER, Akçay Ciblak M, Badur S, Akın Y (2018) Active Surveillance of Influenza A and Other Respiratory Viruses in Children with Influenza-like-illness in Two Seasons. J Infect Dev Ctries 11:944-949. doi: https://doi.org/10.3855/jidc.8867
Section
Original Articles