Clinical features and serum profile of inflammatory biomarkers in patients with brucellosis

  • Jingbo Liu Peking University People's Hospital, Xicheng District, Beijing, China
  • Xiaotao Zhao Peking University People's Hospital, Xicheng District, Beijing, China
Keywords: brucellosis, Brucellosis, Brucella melitensis, Serum agglutination assay, serum agglutination assay

Abstract

Introduction: Brucellosis is a zoonosis caused by Brucella, a highly infectious Gram-negative coccobacillus that has been isolated from a variety of mammals. Brucella melitensis is considered the most common cause of human brucellosis. The aim of this retrospective study was to evaluate the diagnostic value of serum parameters that relate to Brucella melitensis infection.

Methodology: This investigation retrospectively analyzed the clinical laboratory tests and symptoms of brucellosis, which was confirmed by microbiological and serological methods. A total of 36 patients (31 males, 5 females; mean age 49.17 ± 13.56 years) admitted with brucellosis were included in the study over a three-year period between 2012 and 2015 in Peking University People’s Hospital (PKUPH).

Results: A statistically significant increase was observed in C-reactive protein and erythrocyte sedimentation rate in patients with low titers of serum antibody when compared with those with high titers. No difference was observed between the two groups with respect to the other serum parameters such as procalcitonin or white blood cell count. Two blood culture systems also yielded different results.

Conclusions: In this study, we demonstrated that culture can be improved by using multiple blood culture systems to isolate Brucella melitensis. We also found the different role of inflammatory markers play during the process of brucellosis. The present study may be a helpful reference in the diagnosis of brucellosis.

Author Biographies

Jingbo Liu, Peking University People's Hospital, Xicheng District, Beijing, China

Assistant Researcher of Clinical Laboratory deparment,

Peking University People's Hospital

Xiaotao Zhao, Peking University People's Hospital, Xicheng District, Beijing, China

Chief Physician and Residency Program Coordinator of Clinical Laboratory deparment,

Peking University People's Hospital

Published
2017-12-10
How to Cite
1.
Liu J, Zhao X (2017) Clinical features and serum profile of inflammatory biomarkers in patients with brucellosis. J Infect Dev Ctries 11:840-846. doi: 10.3855/jidc.8872
Section
Original Articles