Antimicrobial susceptibility of microorganisms causing Urinary Tract Infections in Saudi Arabia

  • Bander Balkhi King Saud University, Riyadh, Saudi Arabia
  • Wael Mansy King Saud University, Riyadh, Saudi Arabia
  • Sultan AlGhadeer King Saud University, Riyadh, Saudi Arabia
  • Abdulrahman Alnuaim Johns Hopkins Aramco Healthcare Center, Dhahran, Saudi Arabia
  • Abdullah Alshehri Prince Mohammad Bin Abdulaziz Hospital, Riyadh, Saudi Arabia
  • Ali Somily King Saud University and King Saud University Medical City, Riyadh, Saudi Arabia
Keywords: urinary tract infection, antimicrobial resistance, uropathogen, Saudi Arabia

Abstract

Introduction: Urinary Tract Infections (UTIs) is one of the most common infections worldwide. UTIs remain a challenge to the healthcare system because of the emergence of antimicrobial resistance. The aim of this study is to report the most common UTI-causative organisms associated with the emergence of antimicrobial resistance in Saudi Arabia.

Methodology: a retrospective cross sectional study of 1918 positive urine culture samples of both gender collected over 9 months (May 2015 to February 2016) from a major tertiary hospital in Riyadh, Saudi Arabia.

Results: the median age of individuals involved in the study was 43 years, with males constituting 27.7% only of the population. Among cases deemed complicated (81.1%), common causes were diabetes, pregnancy, and immunocompromization, comprising 24.7%, 11.9%, and 10.8%, respectively. 

Escherichia coli (52%) was the most common uropathogen, followed by Klebsiella pneumoniae (15%), Pseudomonas aeruginosa (8%) Streptococcus agalactiae (Group B streptococcus) (7%), and Enterococcus faecalis (5%). Overall sensitivity studies showed the most highly resistant uropathogen was Escherichia coli (60%) followed by Klebsiella pneumoniae (16%), Pseudomonas aeruginosa (4%) Enterococcus faecalis (3%), and Enterobacter cloacae (2%). Concerning the first defense antibiotics prescribed for UTI, E. coli was most frequently resistant to Sulfamethoxazole/Trimethoprim (47%) followed by ciprofloxacin (34%). K. pneumoniae was most frequently resistant to Sulfamethoxazole/trimethoprim (35%) followed by cefuroxime (30%), while P. aeruginosa to ciprofloxacin (13%).

Conclusion: Because of a high level of antimicrobial resistance amongst uropathogens in Saudi Arabia, the development of regional and national UTI guidelines is recommended.

Author Biographies

Bander Balkhi, King Saud University, Riyadh, Saudi Arabia

Department of Clinical Pharmacy, College of Pharmacy

Wael Mansy, King Saud University, Riyadh, Saudi Arabia

Department of Clinical Pharmacy, College of Pharmacy

Sultan AlGhadeer, King Saud University, Riyadh, Saudi Arabia

Department of Clinical Pharmacy, College of Pharmacy

Ali Somily, King Saud University and King Saud University Medical City, Riyadh, Saudi Arabia

Department of Pathology and Laboratory Medicine, College of Medicine

Published
2018-04-30
How to Cite
1.
Balkhi B, Mansy W, AlGhadeer S, Alnuaim A, Alshehri A, Somily A (2018) Antimicrobial susceptibility of microorganisms causing Urinary Tract Infections in Saudi Arabia. J Infect Dev Ctries 12:220-227. doi: https://doi.org/10.3855/jidc.9517
Section
Original Articles