The Human papillomavirus among women living with Human Immunodeficiency Virus in Morocco A prospective cross-sectional study

  • Ahd Ouladlahsen Service des maladies Infectieuses, CHU Ibn Rochd, Casablanca, Morocco
  • Naouar Fayssel Institut Pasteur du Maroc, Casablanca, Morocco
  • Rajaa Bensghir Service des maladies Infectieuses, CHU Ibn Rochd, Casablanca, Morocco
  • Hanâ Baba Institut Pasteur du Maroc, Casablanca, Morocco
  • Hassan Lamdini Service des maladies Infectieuses, CHU Ibn Rochd, Casablanca, Morocco
  • Mustapha Sodqi Service des maladies Infectieuses, CHU Ibn Rochd, Casablanca, Morocco
  • Latifa Marih Service des maladies Infectieuses, CHU Ibn Rochd, Casablanca, Morocco
  • Meryem Essebbani Service des maladies Infectieuses, CHU Ibn Rochd, Casablanca, Morocco
  • Sellama Nadifi Faculté de Médecine et de Pharmacie, Casablanca, Morocco
  • Soumaya Benjelloun Institut Pasteur du Maroc, Casablanca, Morocco
  • Hakima Himmich Association de Lutte Contre Le Sida, Casablanca, Morocco
  • Abdelfattah Chakib Service des maladies Infectieuses, CHU Ibn Rochd, Casablanca, Morocco
  • Lahcen Wakrim Institut Pasteur du Maroc, Casablanca, Morocco
  • Kamal Marhoum El Filali Service des maladies Infectieuses, CHU Ibn Rochd, Casablanca, Morocco
  • Sayeh Ezzikouri Institut Pasteur du Maroc, Casablanca, Morocco
Keywords: AIDS, cervical cytology, human immunodeficiency virus, human papillomavirus, prevalence

Abstract

Introduction: Women infected with human immunodeficiency virus (HIV) have a higher risk of contracting human papillomavirus (HPV) infections and are more prone to develop cervical cancer. The objective of this study was to determine the prevalence of HPV and its association with risk factors among Moroccan women living with HIV/AIDS.

Methodology: We enrolled 251 HIV-infected non-pregnant women in Morocco from February 2013 to September 2016. Sociodemographic, lifestyles, behavioral and clinical data were collected. Polymerase chain reaction followed by sequencing were performed for molecular detection and HPV genotyping in cervical samples, respectively.

Results: Abnormal cervical smears were found in 34/246 patients (13.82%). The overall prevalence of HPV was 74.50%. HPV 58 was the most prevalent (39.29%) followed by HPV 18 (10.71%), HPV 70 (8.93%), HPV 33 (7.14%), HPV 6 (6.25%) and other genotypes (< 3%). Overall, high-risk HPV (HR-HPV) types were present in 75% (84/112) of patients and the prevalence of HR-HPV types in samples with abnormal Pap was higher than in normal Pap (55/83, 66.27% vs. 28/83, 33.33%, p < 0.0001). Univariate analyses showed that none of the socio-demographic and behaviors factors was associated with HPV infection. Moreover, Pap results were not affected by HPV status (p = 0.532). Whereas, CD4 T-cell counts above 200/mm3 at enrolment were apparently not protective to HPV infection. We found a high prevalence of HPV infection and HR-HPV types among HIV-positive women that significantly associated with abnormal Pap.

Conclusion: Our findings suggest a high prevalence of HPV infection with high-risk types was observed among HIV-positive women warrant to implement a regular screening by Pap smear.

Author Biographies

Naouar Fayssel, Institut Pasteur du Maroc, Casablanca, Morocco

Virology Unit, Immunovirology Laboratory,

Hanâ Baba, Institut Pasteur du Maroc, Casablanca, Morocco

Virology Unit, Immunovirology Laborator

Sellama Nadifi, Faculté de Médecine et de Pharmacie, Casablanca, Morocco

Laboratoire de génétique médicale et de pathologie moléculaire

Soumaya Benjelloun, Institut Pasteur du Maroc, Casablanca, Morocco

Virology Unit, Viral Hepatitis Laboratory

Lahcen Wakrim, Institut Pasteur du Maroc, Casablanca, Morocco

Virology Unit, Immunovirology Laboratory

Sayeh Ezzikouri, Institut Pasteur du Maroc, Casablanca, Morocco

Virology Unit, Viral Hepatitis Laboratory

Published
2018-06-30
How to Cite
1.
Ouladlahsen A, Fayssel N, Bensghir R, Baba H, Lamdini H, Sodqi M, Marih L, Essebbani M, Nadifi S, Benjelloun S, Himmich H, Chakib A, Wakrim L, Marhoum El Filali K, Ezzikouri S (2018) The Human papillomavirus among women living with Human Immunodeficiency Virus in Morocco A prospective cross-sectional study. J Infect Dev Ctries 12:477-484. doi: https://doi.org/10.3855/jidc.9711
Section
Original Articles