Risk factors of severe hand, foot and mouth disease in Shantou, China: a case-control study

  • Chunhua Liu The First Affiliated Hospital of Shantou University Medical College, Shantou, China
  • Kaiyan Wang Shantou University Medical College , Shantou, China
  • Niyang Lin The First Affiliated Hospital of Shantou University Medical College, Shantou, China
  • Jianling Cai The First Affiliated Hospital of Shantou University Medical College, Shantou, China
  • Binglin Cui The First Affiliated Hospital of Shantou University Medical College, Shantou, China
  • Beiyan Wu The First Affiliated Hospital of Shantou University Medical College, Shantou, China
Keywords: Hand, foot and mouth disease, children, risk factor, enteroviruses, diagnosis

Abstract

Introduction: In clinical perspectives, how to distinguish a small proportion of children at risk of developing neurological complications from a large number of children with mild symptoms still remains a challenge for primary care doctors.

Methodology: From January 2012 to December 2015, 225 cases with severe hand, foot and mouth disease (HFMD) matched with 492 controls were enrolled in the age-matched, case-control study. Continuous variables were examined by univariate analysis using a chi-squared or Fisher’s exact test, and categorical variables were reported by relative risks (odd’s ratio). Multivariate logistic regression was used to analyze the independent risk factors for severe HFMD.

Results: Peak body temperature over 37.5℃,total duration of fever over 3 days, lethargy, enterovirus 71 (EV71) infection were independent risk factors for severe HFMD.

Conclusions: Peak body temperature over 37.5℃,total duration of fever over 3 days, lethargy, EV71 infection were independent risk factors for severe HFMD.

Published
2018-05-31
How to Cite
1.
Liu C, Wang K, Lin N, Cai J, Cui B, Wu B (2018) Risk factors of severe hand, foot and mouth disease in Shantou, China: a case-control study. J Infect Dev Ctries 12:359-364. doi: https://doi.org/10.3855/jidc.9845
Section
Original Articles