Hypoalbuminemia predicts intensive care need among adult inpatients with community acquired pneumonia: a cross sectional study

  • Muhammad Adnan Fatima Jinnah Medical University, Lahore, Pakistan
  • Naheed Hashmat Sir Ganga Ram Hospital, Lahore, Pakistan
  • Muhammad Latif Akhtar Saeed Medical and Dental College, Lahore, Pakistan
  • Zahra Ali Fatima Jinnah Medical University, Lahore, Pakistan
  • Tayyaba Rahat Fatima Jinnah Medical University, Lahore, Pakistan
Keywords: Blood urea nitrogen, hypoalbuminemia, hospitalization, intensive care unit, pneumonia

Abstract

Introduction: Various scales helped physicians to decide the site of care of pneumonia patients, but had certain limitations. Literature review suggested that serum albumin and B/A ratio predict the site of care but more evidences were required. Therefore, the study was aimed to evaluate the role of serum albumin and B/A ratio in the prediction of intensive care need among patients with community acquired pneumonia.

Methodology: The cross-sectional analytical study enrolled 134 adult inpatients with pneumonia from Sir Ganga Ram Hospital, Lahore, Pakistan during September 2014 to December 2016. Serum albumin, creatinine and urea levels were estimated; and BUN, B/A ratio and CURB-65 scores were calculated to predict the need of ICU.

Results: Overall mean age was 50 ± 21 years, and 54.5% patients were females. The patients (19.4%) who required treatment in ICU had significantly lower albumin levels (p = 0.001); elevated BUN levels (p = 0.003), B/A ratio (p = 0.001) and CURB-65 score (p = 0.038); and longer hospital stay (p = 0.002). Hypoalbuminemia showed significant association with the requirement of ICU (OR: 7.956; p = 0.001). The optimal cut-off point of serum albumin to predict ICU need was 3.4 g/dL (50% sensitivity; 89% specificity). Low serum albumin was revealed as a good predictor of requiring treatment in ICU (AUC 0.718).

Conclusions: Hypoalbuminemia was a good predictor of requiring ICU treatment. Elevated B/A ratio and BUN levels showed significant association with ICU need. Serum albumin estimation before hospitalization might be used independently or additional with established criteria to decide the site of care.

Published
2018-08-31
How to Cite
1.
Adnan M, Hashmat N, Latif M, Ali Z, Rahat T (2018) Hypoalbuminemia predicts intensive care need among adult inpatients with community acquired pneumonia: a cross sectional study. J Infect Dev Ctries 12:636-641. doi: https://doi.org/10.3855/jidc.9971
Section
Original Articles